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蜂胶通过增加活性氧来增强中性粒细胞对白色念珠菌的反应。

Propolis increases neutrophils response against Candida albicans through the increase of reactive oxygen species.

机构信息

Bioscience & Physiopathology Graduate Program, Universidade Estadual de Maringá (UEM), Av Colombo 5790, 87025-210 Maringá, PR, Brazil.

Health Sciences Graduate Program, Universidade Estadual de Maringá (UEM), Av Colombo 5790, 87025-210 Maringá, PR, Brazil.

出版信息

Future Microbiol. 2018 Feb;13:221-230. doi: 10.2217/fmb-2017-0112. Epub 2018 Jan 5.

DOI:10.2217/fmb-2017-0112
PMID:29302986
Abstract

AIM

To investigate whether Brazilian green propolis improves the immune response against recurrent form isolate recurrent vulvovaginal candidiasis (RVVC) caused by Candida albicans by increasing neutrophil oxidative burst.

MATERIALS & METHODS: We evaluated oxidant species production, oxygen consumption, microbicidal activity and myeloperoxidase activity in neutrophils previously treated with propolis and activated with different isolates of C. albicans (RVVC), vulvovaginal candidiasis, asymptomatic isolates and the reference strain.

RESULTS

Propolis significantly increased oxidant species production, oxygen consumption, microbicidal activity and myeloperoxidase activity of neutrophils against different isolates of C. albicans including RVVC isolate that are considered resistant to the microbicidal activity of neutrophils.

CONCLUSION

Brazilian green propolis may increase neutrophil burst oxidative response to RVVC leading to an efficient removal of C. albicans.

摘要

目的

研究巴西绿蜂胶是否通过增加中性粒细胞氧化爆发来改善对白念珠菌引起的复发性外阴阴道念珠菌病（RVVC）的免疫反应。

材料与方法

我们评估了经蜂胶预处理并经不同白念珠菌（RVVC、外阴阴道念珠菌病、无症状分离株和参考株）分离株激活后的中性粒细胞中活性氧物种的产生、耗氧量、杀菌活性和髓过氧化物酶活性。

结果

蜂胶显著增加了中性粒细胞对不同白念珠菌分离株包括被认为对中性粒细胞杀菌活性有抗性的 RVVC 分离株的活性氧物种产生、耗氧量、杀菌活性和髓过氧化物酶活性。

结论

巴西绿蜂胶可能增加 RVVC 中性粒细胞的氧化爆发反应，从而有效清除白念珠菌。

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