Avakian A P, Dick J W, Derieux W T
Department of Poultry Science, Clemson University, South Carolina 29634-0379.
Avian Dis. 1989 Jan-Mar;33(1):97-102.
Broiler minibreeder hens were vaccinated for protection against fowl cholera at 12 and 21 weeks of age using several vaccination schemes, which included a live Pasteurella multocida (CU strain) vaccine, two commercial polyvalent fowl cholera oil-based bacterins, and two experimentally prepared polyvalent oil-based bacterins. Some treatment groups received only live or killed vaccines, whereas others received a live vaccine at 12 weeks followed by a killed product at 21 weeks. At 42 weeks of age, all birds that received the live CU vaccine twice or once followed by a bacterin survived challenge. Birds that received killed vaccines only were significantly less protected but still showed a respectable survival rate of 86%. All unvaccinated controls died within 72 hr after challenge. At 72 weeks of age, overall protection was lower than that at 42 weeks, regardless of vaccination treatment. Antibody titers were usually higher in birds that received bacterins than in those receiving live vaccines, yet overall protection was still greater in those birds that received the live cholera vaccine twice.
肉种鸡母鸡在12周龄和21周龄时采用多种疫苗接种方案进行了禽霍乱疫苗接种，其中包括一种多杀性巴氏杆菌（CU株）活疫苗、两种市售多价禽霍乱油乳剂灭活疫苗，以及两种实验制备的多价油乳剂灭活疫苗。一些处理组仅接种了活疫苗或灭活疫苗，而其他组在12周龄时接种了活疫苗，在21周龄时接种了灭活产品。在42周龄时，所有接受两次或一次CU活疫苗接种后再接种灭活疫苗的鸡在攻毒后存活下来。仅接受灭活疫苗接种的鸡受到的保护明显较差，但仍显示出86%的可观存活率。所有未接种疫苗的对照鸡在攻毒后72小时内死亡。在72周龄时，无论疫苗接种处理如何，总体保护率均低于42周龄时。接受灭活疫苗接种的鸡的抗体滴度通常高于接受活疫苗接种的鸡，但接受两次活霍乱疫苗接种的鸡的总体保护率仍然更高。
