Forrester J V, Stott D I, Hercus K M
Department of Ophthalmology, University of Aberdeen.
Br J Ophthalmol. 1989 Feb;73(2):155-9. doi: 10.1136/bjo.73.2.155.
The antibody responses to human and bovine retinal S antigen in the sera of patients with uveitis from various causes were compared with those of a group of healthy volunteers who were fully screened for signs of eye disease. Antiretinal antibodies were found with equal frequency and through the same range of titres in patients and controls, irrespective of the nature or activity of the uveitis. These findings were confirmed by spectrotypic analysis of sera from patients and controls where the predominant serum antibody response was polyclonal. In a small group of patients with retinal vasculitis there was an additional monoclonal response, indicating clonal expansion of a single lymphocyte subset. The prevalence of serum antibodies to retinal antigens in the normal population may indicate a protective role for 'natural' autoantibodies, as has recently been suggested for autoimmune diseases generally.
将各种病因的葡萄膜炎患者血清中针对人及牛视网膜S抗原的抗体反应，与一组经过全面眼部疾病体征筛查的健康志愿者的抗体反应进行了比较。在患者和对照组中，无论葡萄膜炎的性质或活动程度如何，抗视网膜抗体的出现频率及滴度范围均相同。对患者和对照组血清进行的光谱分型分析证实了这些发现，其中主要的血清抗体反应为多克隆反应。在一小部分视网膜血管炎患者中，还存在额外的单克隆反应，表明单个淋巴细胞亚群发生了克隆性扩增。正常人群中血清抗视网膜抗原抗体的流行情况可能表明“天然”自身抗体具有保护作用，正如最近对一般自身免疫性疾病所提出的那样。
