Clough J D, Valenzuela R
Am J Med. 1980 Jan;68(1):80-5. doi: 10.1016/0002-9343(80)90169-2.
Using a newly-developed solid-phase radioimmunoassay for DNA-binding immunoglobulins, immunoglobulin M (IgM), immunoglobulin G (IgG) and immunoglobulin A (IgA) anti-DNA were measured in serums from 11 patients with active untreated systemic lupus erythematosus (SLE) with nephritis. All patients underwent renal biopsy and were classified according to standard criteria as having diffuse or focal proliferative glomerulonephritis. Although both groups had almost identical total anti-DNA (13.1 versus 13.9 micrograms/ml, respectively), the IgM to IgG ratio was significantly higher (p less than 0.01) in the group with DPGN (7.51) than in the group with FPGN (1.10). We suggest that the switchover mechanism from IgM to IgG antibody production is more profoundly impaired in SLE with severe renal disease than in SLE with mild renal disease.
采用一种新开发的用于检测DNA结合免疫球蛋白的固相放射免疫分析法，对11例未经治疗的活动性狼疮性肾炎患者血清中的免疫球蛋白M（IgM）、免疫球蛋白G（IgG）和免疫球蛋白A（IgA）抗DNA进行了检测。所有患者均接受了肾活检，并根据标准标准分类为弥漫性或局灶性增殖性肾小球肾炎。尽管两组的总抗DNA水平几乎相同（分别为13.1微克/毫升和13.9微克/毫升），但弥漫性增殖性肾小球肾炎组的IgM与IgG比值（7.51）显著高于局灶性增殖性肾小球肾炎组（1.10）（p<0.01）。我们认为，与轻度肾脏疾病的系统性红斑狼疮相比，严重肾脏疾病的系统性红斑狼疮中从IgM抗体产生向IgG抗体产生的转换机制受损更为严重。
