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Adoptive transfer of IL-10 regulatory B cells decreases myeloid-derived macrophages in the central nervous system in a transgenic amyotrophic lateral sclerosis model.

作者信息

Pennati Andrea, Asress Seneshaw, Glass Jonathan D, Galipeau Jacques

机构信息

Department of Medicine, University of Wisconsin School of Medicine and Public Health and University of Wisconsin Carbone Cancer Center, Madison, 53706, USA, WI.

Department of Neurology, Emory University, Atlanta, 30322, USA, GA.

出版信息

Cell Mol Immunol. 2018 Jul;15(7):727-730. doi: 10.1038/cmi.2017.152. Epub 2018 Jan 8.

DOI:10.1038/cmi.2017.152
PMID:29307886
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6123431/
Abstract
摘要

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本文引用的文献

1
Regulatory B Cells Induce Formation of IL-10-Expressing T Cells in Mice with Autoimmune Neuroinflammation.调节性B细胞在患有自身免疫性神经炎症的小鼠中诱导表达白细胞介素-10的T细胞形成。
J Neurosci. 2016 Dec 14;36(50):12598-12610. doi: 10.1523/JNEUROSCI.1994-16.2016. Epub 2016 Nov 7.
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A robust, good manufacturing practice-compliant, clinical-scale procedure to generate regulatory T cells from patients with amyotrophic lateral sclerosis for adoptive cell therapy.一种稳健的、符合药品生产质量管理规范的临床规模程序，用于从肌萎缩侧索硬化症患者中生成调节性T细胞以进行过继性细胞治疗。
Cytotherapy. 2016 Oct;18(10):1312-24. doi: 10.1016/j.jcyt.2016.06.012. Epub 2016 Aug 3.
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An update on immunopathogenesis, diagnosis, and treatment of multiple sclerosis.多发性硬化症免疫发病机制、诊断及治疗的最新进展
Brain Behav. 2015 Sep;5(9):e00362. doi: 10.1002/brb3.362. Epub 2015 Aug 3.
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Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis.肌萎缩侧索硬化症中的保护性和毒性神经炎症
Neurotherapeutics. 2015 Apr;12(2):364-75. doi: 10.1007/s13311-014-0329-3.
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Immune-mediated mechanisms in the pathoprogression of amyotrophic lateral sclerosis.免疫介导机制在肌萎缩侧索硬化症的发病机制中的作用。
J Neuroimmune Pharmacol. 2013 Sep;8(4):888-99. doi: 10.1007/s11481-013-9489-x. Epub 2013 Jul 25.
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Feasibility, safety, and preliminary proof of principles of autologous neural stem cell treatment combined with T-cell vaccination for ALS patients.自体神经干细胞治疗联合 T 细胞疫苗治疗 ALS 患者的可行性、安全性和初步原理验证。
Cell Transplant. 2012;21 Suppl 1:S57-63. doi: 10.3727/096368912X633770.
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Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis.内源性调节性 T 淋巴细胞可改善小鼠肌萎缩侧索硬化症，并与肌萎缩侧索硬化症患者的疾病进展相关。
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A granulocyte-macrophage colony-stimulating factor and interleukin-15 fusokine induces a regulatory B cell population with immune suppressive properties.粒细胞-巨噬细胞集落刺激因子与白细胞介素-15融合因子可诱导具有免疫抑制特性的调节性B细胞群体。
Nat Med. 2009 Sep;15(9):1038-45. doi: 10.1038/nm.2003. Epub 2009 Aug 9.
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Inflammation in amyotrophic lateral sclerosis spinal cord and brain is mediated by activated macrophages, mast cells and T cells.肌萎缩侧索硬化症患者脊髓和大脑中的炎症由活化的巨噬细胞、肥大细胞和T细胞介导。
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Current treatment of neuromuscular diseases.神经肌肉疾病的当前治疗方法。
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