Netto C A, Izquierdo I
Braz J Med Biol Res. 1984;17(3-4):349-51.
Electroconvulsive shock (ECS) is used in the treatment of depression and causes antero- and retrograde amnesia as a side effect. One of the many neurochemical effects of ECS is depletion of brain beta-endorphin and Met-enkephalin. These two opioid peptides cause antero- and retrograde amnesia also. Naloxone antagonizes the amnestic effect of ECS and of the opioid peptides. Thus, it is possible that the amnestic effect of ECS is mediated by an endogenous release of the peptides. Surgical posterior hypothalamic deafferentation, but not anterior deafferentation or fornix transection, abolishes the amnestic effect of ECS. This suggests that the hyperactivation of endogenous opioid systems by ECS that leads to amnesia is mediated by posterior ascending fibers to the hypothalamus. The relevance of these considerations to the treatment of depression merits investigation.
电休克（ECS）用于治疗抑郁症，会导致顺行性和逆行性失忆作为副作用。ECS众多神经化学效应之一是脑内β-内啡肽和甲硫氨酸脑啡肽的耗竭。这两种阿片肽也会导致顺行性和逆行性失忆。纳洛酮可拮抗ECS和阿片肽的失忆效应。因此，ECS的失忆效应可能是由这些肽的内源性释放介导的。手术切断下丘脑后部传入神经，但不是前部传入神经切断或穹窿横断，可消除ECS的失忆效应。这表明ECS导致失忆的内源性阿片系统的过度激活是由下丘脑后部的上行纤维介导的。这些考虑因素与抑郁症治疗的相关性值得研究。
