Wu Xiufa, Mao Wenjing, He Peijie, Wei Chunsheng
a Department of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose and Throat Hospital , Fudan University , Shanghai , PR China.
Acta Otolaryngol. 2018 Jun;138(6):567-573. doi: 10.1080/00016489.2017.1419577. Epub 2018 Jan 8.
To evaluate three methods for treating adult laryngeal hemangiomas: conventional chemotherapy, CO laser combined with chemotherapy, and KTP laser. And to identify risk factors that affected the prognosis of the lesions.
A retrospective analysis was performed on the data from patients with adult laryngeal hemangiomas treated by one of three aforementioned methods, the curative efficacy, and safety of those methods was compared.
All cases were confirmed by suspension micro-laryngoscope examination. Pre- and post-treatment clinical photographs were taken and the outcomes were graded. Thirty-eight patients in 48 different cases were enrolled in the study between June 2010 and June 2016, and some patients were treated more than once. The treatment efficacy of the KTP laser was higher than that of chemotherapy according to the Kruskal-Wallis ANOVA test; however, the ordinal logistic regression showed that the choice of surgical procedure did not affect the treatment results; only the size of the bases of the lesions affected the prognosis of adult laryngeal hemangiomas.
Pingyangmycin injection, KTP laser, and CO laser combined with chemotherapy are safe and effective methods for the treatment of adult laryngeal hemangiomas. The size of base of the lesion affects the prognosis of the hemangiomas.
评估三种治疗成人喉血管瘤的方法：传统化疗、CO激光联合化疗以及KTP激光。并确定影响病变预后的危险因素。
对采用上述三种方法之一治疗的成人喉血管瘤患者的数据进行回顾性分析，比较这些方法的疗效和安全性。
所有病例均经悬吊式显微喉镜检查确诊。治疗前后均拍摄临床照片并对结果进行分级。2010年6月至2016年6月期间，48例不同病例中的38例患者纳入本研究，部分患者接受了不止一次治疗。根据Kruskal-Wallis方差分析，KTP激光的治疗效果高于化疗；然而，有序逻辑回归显示手术方式的选择并不影响治疗结果；只有病变基底的大小影响成人喉血管瘤的预后。
平阳霉素注射、KTP激光以及CO激光联合化疗是治疗成人喉血管瘤的安全有效方法。病变基底的大小影响血管瘤的预后。
