内啡肽在败血性休克中的作用：一项针对烧伤患者的初步研究。

The role of endorphins in septicaemic shock: a pilot study in burned patients.

作者信息

Elliot D, Everitt A S, Gault D, Quaba A A, Hackett M E, Howlett T A, Tomlin S J, Rees L H

出版信息

Burns Incl Therm Inj. 1985 Aug;11(6):387-92. doi: 10.1016/0305-4179(85)90142-1.

Abstract

There is recent evidence that circulating opioid peptides, or 'endorphins', act as chemical messengers responsible for the induction of the complex cardiovascular changes leading to hypotension in septicaemic shock. The pilot study of an investigation of opioid peptides in septicaemia in burned patients is presented. Serial measurements of plasma beta-endorphin and metenkephalin were performed throughout the recovery of six patients with large burns (20-70 per cent BSA). Our preliminary findings concur with previous evidence that opioid peptides may play a role in the hypotension of septicaemic shock.

摘要

最近有证据表明，循环中的阿片肽，即“内啡肽”，作为化学信使，负责引发导致败血症性休克低血压的复杂心血管变化。本文介绍了一项对烧伤患者败血症中阿片肽进行调查的初步研究。在6例大面积烧伤（烧伤面积占体表面积的20%-70%）患者的康复过程中，对血浆β-内啡肽和甲硫脑啡肽进行了连续测量。我们的初步研究结果与之前的证据一致，即阿片肽可能在败血症性休克的低血压中起作用。