正常女性运动过程中β-内啡肽和甲硫氨酸脑啡肽的释放：对训练的反应。
Release of beta endorphin and met-enkephalin during exercise in normal women: response to training.
作者信息
Howlett T A, Tomlin S, Ngahfoong L, Rees L H, Bullen B A, Skrinar G S, McArthur J W
出版信息
Br Med J (Clin Res Ed). 1984 Jun 30;288(6435):1950-2. doi: 10.1136/bmj.288.6435.1950.
Abstract
Plasma beta endorphin and met-enkephalin concentrations were measured in response to treadmill exercises in 15 normal women before, during, and after an intensive programme of exercise training. Significant release of beta endorphin occurred in all three test runs, and the pattern and amount of release were not altered by training. Before training dramatic release of met-enkephalin was observed in seven subjects and smaller rises observed in a further four, and this response was almost abolished by training. This represents the first observed "physiological" stimulus to met-enkephalin release. Endogenous opioid peptides play a part in adaptive changes to exercise training and probably contribute to the menstrual disturbances of women athletes.
摘要
在15名正常女性进行强化运动训练计划之前、期间和之后，测量了她们在跑步机运动时血浆β-内啡肽和甲硫氨酸脑啡肽的浓度。在所有三次测试中均出现了β-内啡肽的显著释放，且释放模式和释放量并未因训练而改变。训练前，7名受试者观察到甲硫氨酸脑啡肽的急剧释放，另外4名受试者观察到较小幅度的升高，而这种反应在训练后几乎消失。这是首次观察到的对甲硫氨酸脑啡肽释放的“生理”刺激。内源性阿片肽在运动训练的适应性变化中起作用，并且可能导致女运动员的月经紊乱。
相似文献
1
Release of beta endorphin and met-enkephalin during exercise in normal women: response to training.正常女性运动过程中β-内啡肽和甲硫氨酸脑啡肽的释放：对训练的反应。
Br Med J (Clin Res Ed). 1984 Jun 30;288(6435):1950-2. doi: 10.1136/bmj.288.6435.1950.
2
Assessment of plasma opioid peptides, beta-endorphin and met-enkephalin, at the end of an international nordic ski race.在一场国际北欧滑雪比赛结束时对血浆阿片肽、β-内啡肽和甲硫氨酸脑啡肽进行评估。
Eur J Appl Physiol Occup Physiol. 1987;56(3):281-6. doi: 10.1007/BF00690893.
3
The effect of surgery on plasma beta-endorphin and methionine-enkephalin.手术对血浆β-内啡肽和甲硫氨酸脑啡肽的影响。
Neurosci Lett. 1985 Mar 22;55(1):17-21. doi: 10.1016/0304-3940(85)90305-2.
4
Exercise induced asthma and endogenous opioids.运动诱发性哮喘与内源性阿片类物质
Thorax. 1986 May;41(5):350-4. doi: 10.1136/thx.41.5.350.
5
Plasma beta-endorphin, beta-lipotropin, and met-enkephalin concentrations during pregnancy in normal and drug-addicted women and their newborn.正常及吸毒成瘾女性孕期及其新生儿血浆中β-内啡肽、β-促脂素和甲硫氨酸脑啡肽的浓度
J Clin Endocrinol Metab. 1983 Sep;57(3):537-43. doi: 10.1210/jcem-57-3-537.
6
Endogenous opioid peptides in pregnancy.
Br J Obstet Gynaecol. 1983 Jun;90(6):535-8. doi: 10.1111/j.1471-0528.1983.tb08963.x.
7
Plasma opioid peptide responses during heat acclimation in humans.人体热适应过程中的血浆阿片肽反应。
Peptides. 1987 Jul-Aug;8(4):715-9. doi: 10.1016/0196-9781(87)90048-9.
8
Endorphins: "opiates for the masses".内啡肽：“大众的鸦片”。
Med Sci Sports Exerc. 1985 Feb;17(1):101-5.
9
Nitrous oxide inhalation does not influence plasma concentrations of beta-endorphin or Met-enkephalin-like immunoreactivity.
Br J Anaesth. 1985 Jun;57(6):624-8. doi: 10.1093/bja/57.6.624.
10
Plasma beta-endorphin and met-enkephalin in physiological and pathological conditions.生理和病理条件下的血浆β-内啡肽和甲硫氨酸脑啡肽
Adv Biochem Psychopharmacol. 1982;33:139-49.
引用本文的文献
1
Exercise Patterns and Migraine Management: A Multifaceted Approach.运动模式与偏头痛管理：一种多方面的方法。
Am J Lifestyle Med. 2025 Jun 19:15598276251346394. doi: 10.1177/15598276251346394.
2
Social structure as a strategy to mitigate the costs of group living: a comparison of gelada and guereza monkeys.作为减轻群居生活成本策略的社会结构：狮尾狒和东黑白疣猴的比较
Anim Behav. 2018 Feb;136:53-64. doi: 10.1016/j.anbehav.2017.12.005.
3
Effects of intensive training on menstrual function and certain serum hormones and peptides related to the female reproductive system.强化训练对月经功能及与女性生殖系统相关的某些血清激素和肽的影响。
Medicine (Baltimore). 2017 May;96(21):e6876. doi: 10.1097/MD.0000000000006876.
4
Effects of fitness training on physical fitness parameters and quality of life in human immunodeficiency virus-positive Indian females.健身训练对印度人类免疫缺陷病毒阳性女性的体能参数和生活质量的影响。
Indian J Sex Transm Dis AIDS. 2017 Jan-Jun;38(1):47-53. doi: 10.4103/0253-7184.196886.
5
Effect of Exercise on Ovulation: A Systematic Review.运动对排卵的影响：系统评价。
Sports Med. 2017 Aug;47(8):1555-1567. doi: 10.1007/s40279-016-0669-8.
6
Motor Imagery and Its Effect on Complex Regional Pain Syndrome: An Integrative Review.运动想象及其对复杂性区域疼痛综合征的影响：一项综合综述。
Neurol Int. 2015 Dec 31;7(3):5962. doi: 10.4081/ni.2015.5962. eCollection 2015 Dec 29.
7
Role of Endogenous Opioid System in Ischemic-Induced Late Preconditioning.内源性阿片系统在缺血诱导的延迟预处理中的作用。
PLoS One. 2015 Jul 30;10(7):e0134283. doi: 10.1371/journal.pone.0134283. eCollection 2015.
8
Mechanisms Involved in Exercise-Induced Cardioprotection: A Systematic Review.运动诱导心脏保护的相关机制：一项系统综述
Arq Bras Cardiol. 2015 Jul;105(1):71-81. doi: 10.5935/abc.20150024. Epub 2015 Mar 27.
9
Music and social bonding: "self-other" merging and neurohormonal mechanisms.音乐与社交纽带：“自我-他人”融合与神经激素机制。
Front Psychol. 2014 Sep 30;5:1096. doi: 10.3389/fpsyg.2014.01096. eCollection 2014.
10
Advocating neuroimaging studies of transmitter release in human physical exercise challenges studies.倡导对人类体育锻炼中递质释放进行神经影像学研究对研究提出了挑战。
Open Access J Sports Med. 2010 Sep 6;1:167-75. doi: 10.2147/OAJSM.S12054. eCollection 2010.
本文引用的文献
1
Development of a specific extracted radioimmunoassay for methionine enkephalin in human plasma and cerebrospinal fluid.人血浆和脑脊液中甲硫氨酸脑啡肽特异性提取放射免疫分析法的开发。
J Endocrinol. 1980 Aug;86(2):231-43. doi: 10.1677/joe.0.0860231.
2
Catecholamines, dopamine, and endorphin levels during extreme exercise.极限运动期间的儿茶酚胺、多巴胺和内啡肽水平。
N Engl J Med. 1981 Aug 20;305(8):466-7.
3
The effect of running on plasma beta-endorphin.跑步对血浆β-内啡肽的影响。
Life Sci. 1981 Apr 6;28(14):1637-40. doi: 10.1016/0024-3205(81)90319-2.
4
Plasma melatonin increases during exercise in women.女性运动时血浆褪黑素水平会升高。
J Clin Endocrinol Metab. 1981 Jul;53(1):224-5. doi: 10.1210/jcem-53-1-223.
5
Increases in plasma beta-endorphin/beta-lipotropin immunoreactivity after treadmill running in humans.
J Appl Physiol Respir Environ Exerc Physiol. 1982 May;52(5):1245-9. doi: 10.1152/jappl.1982.52.5.1245.
6
Naloxone inhibits exercise-induced release of PRL and GH in athletes.纳洛酮可抑制运动员运动诱导的催乳素和生长激素释放。
Clin Endocrinol (Oxf). 1983 Feb;18(2):135-8. doi: 10.1111/j.1365-2265.1983.tb03195.x.
7
The effect of naloxone on pulsatile gonadotrophin release in normal subjects.纳洛酮对正常受试者促性腺激素脉冲式释放的影响。
Clin Endocrinol (Oxf). 1981 Mar;14(3):321-4. doi: 10.1111/j.1365-2265.1981.tb00202.x.
8
The opioid control of LH and FSH release: effects of a met-enkephalin analogue and naloxone.阿片类物质对促黄体生成素和促卵泡激素释放的控制：一种甲硫氨酸脑啡肽类似物和纳洛酮的作用。
Clin Endocrinol (Oxf). 1981 Jan;14(1):41-7. doi: 10.1111/j.1365-2265.1981.tb00363.x.
9
The effects of exercise on pubertal progression and reproductive function in girls.运动对女孩青春期发育进程及生殖功能的影响。
J Clin Endocrinol Metab. 1980 Nov;51(5):1150-7. doi: 10.1210/jcem-51-5-1150.
10
Hypothalamic amenorrhea in runners of normal body composition.
Endocr Res Commun. 1980;7(1):13-25. doi: 10.3109/07435808009065956.
Zotero 插件