Jin Liwen, Zhang Wei, Pan Hong, Li Tengyan, Liu Beihong, Zhao Junyang, Wang Binbin
Department of Ophthalmology, Maternal and Children's Hospital, Quanzhou, Fujian, China.
Center for Genetics, National Research Institute for Family Planning, Beijing, China.
Oncotarget. 2017 May 23;8(65):108492-108497. doi: 10.18632/oncotarget.18174. eCollection 2017 Dec 12.
This is a retrospective investigation of patients with Retinoblastoma (RB) conducted from 2013 to 2016 at the Quanzhou Maternal and Child Health Hospital (China). Demographic and clinical characteristics, treatment outcomes, and risk factors were studied. In total, 436 patients were included in the study. Most of the findings obtained in this study are consistent with other previous reports. The male: female ratio was 1.41:1, and the unilateral: bilateral ratio was 1.51:1. Leukocoria was the most common presenting sign (79.44%), followed by strabismus (12.38%). While, the overall rates of enucleation (15.82%) and mortality (0.92%) were markedly lower than in other reports of RB in Chinese, and most of the patients received conservative therapy. There were signficant differences ( < 0.001) in the age of at first sign and diagnosis, and treatment modalities between patients with bilateral and unilateral RB. The treatment modalities did not show a specific trend over the 3-year study period. Our results suggest that an incorrect initial diagnosis and long lag time may be risk factors for ineffective treatment and a poor prognosis in patients with RB. This was a comprehensive retrospective investigation in which the sample size exceeded most previous retrospective investigations of RB. Our study confirmed that early detection, accurate diagnosis, and active intervention are conducive to control of retention of patients' vision. Fundus examinations, education regarding the early signs of RB, and optimization of the therapeutic strategy of RB may play important roles in ocular health.
这是一项于2013年至2016年在中国泉州市妇幼保健院对视网膜母细胞瘤（RB）患者进行的回顾性调查。研究了人口统计学和临床特征、治疗结果及危险因素。该研究共纳入436例患者。本研究获得的大多数结果与之前的其他报告一致。男女比例为1.41:1，单眼与双眼比例为1.51:1。白瞳症是最常见的临床表现（79.44%），其次是斜视（12.38%）。同时，眼球摘除率（15.82%）和死亡率（0.92%）明显低于其他关于中国RB的报告，且大多数患者接受了保守治疗。双眼和单眼RB患者在首次出现症状和诊断的年龄以及治疗方式上存在显著差异（<0.001）。在3年的研究期间，治疗方式未呈现特定趋势。我们的结果表明，初始诊断错误和较长的延迟时间可能是RB患者治疗无效和预后不良的危险因素。这是一项样本量超过大多数之前RB回顾性调查的全面回顾性研究。我们的研究证实，早期发现、准确诊断和积极干预有利于控制患者视力的保留。眼底检查、关于RB早期体征的教育以及RB治疗策略的优化可能对眼部健康起到重要作用。
