澳大利亚原住民中私人电泳变异的频率及突变率的间接估计
The frequency of private electrophoretic variants in Australian aborigines and indirect estimates of mutation rate.
作者信息
Bhatia K K, Blake N M, Kirk R L
出版信息
Am J Hum Genet. 1979 Nov;31(6):731-40.
Abstract
The number of "private" electrophoretic variants of enzymes controlled by 25 loci has been used to obtain estimates of mutation rate in Australian Aborigines. Three different methods yield values of 6.11 X 10(-6), 2.78 X 10(-6), and 12.86 X 10(-6)/locus per generation for the total sample of Aborigines. One tribal population of Waljbiri in central Australia gives values of 2.99 X 10(-6) and 2.04 X 10(-6) for two of the methods, the third being unapplicable. The mean mutation rate for the total Aboriginal sample of 7.25 X 10(-6) is very similar to the value obtained by Neel and his colleagues for Amerindians in South America.
摘要
由25个基因座控制的酶的“私有”电泳变体数量已被用于估算澳大利亚原住民的突变率。三种不同方法得出的澳大利亚原住民总样本的突变率分别为每代每个基因座6.11×10⁻⁶、2.78×10⁻⁶和12.86×10⁻⁶。澳大利亚中部的一个瓦尔比里部落群体，其中两种方法得出的值分别为2.99×10⁻⁶和2.04×10⁻⁶，第三种方法不适用。澳大利亚原住民总样本的平均突变率为7.25×10⁻⁶，与尼尔及其同事在南美洲对美洲印第安人得出的值非常相似。
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引用本文的文献
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2
Expected number of rare alleles per locus in a sample and estimation of mutation rates.样本中每个基因座的稀有等位基因预期数量及突变率估计。
Am J Hum Genet. 1981 May;33(3):481-4.
3
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A "disproportion" between the frequency of rare electropmorphs and enzyme deficiency variants in Amerindians.美洲印第安人中罕见电泳变体的频率与酶缺乏变体之间的“不均衡”。
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本文引用的文献
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Founder effect and number of private polymorphisms observed in Amerindian tribes.奠基者效应与美洲印第安部落中观察到的私有多态性数量
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