探寻原子弹爆炸幸存者子女中影响蛋白质结构的突变：初步报告。
Search for mutations affecting protein structure in children of atomic bomb survivors: preliminary report.
作者信息
Neel J V, Satoh C, Hamilton H B, Otake M, Goriki K, Kageoka T, Fujita M, Neriishi S, Asakawa J
出版信息
Proc Natl Acad Sci U S A. 1980 Jul;77(7):4221-5. doi: 10.1073/pnas.77.7.4221.
Abstract
A total of 289,868 locus tests, based on 28 different protein phenotypes and using one-dimensional electrophoresis to detect variant proteins, has yielded one probable mutation in the offspring of "proximally exposed" parents, who received an estimated average gonadal exposure of 31 to 39 rem in the atomic bombings of Hiroshima and Nagasaki. There were no mutations in 208,196 locus tests involving children of "distally exposed" parents, who had essentially no radiation exposure.
摘要
基于28种不同蛋白质表型并使用一维电泳检测变异蛋白质，总共进行了289,868次基因座检测，在广岛和长崎原子弹爆炸中估计平均性腺暴露量为31至39雷姆的“近端暴露”父母的后代中发现了一个可能的突变。在涉及“远端暴露”父母的孩子（基本上没有辐射暴露）的208,196次基因座检测中未发现突变。
相似文献
1
Search for mutations affecting protein structure in children of atomic bomb survivors: preliminary report.探寻原子弹爆炸幸存者子女中影响蛋白质结构的突变：初步报告。
Proc Natl Acad Sci U S A. 1980 Jul;77(7):4221-5. doi: 10.1073/pnas.77.7.4221.
2
Search for mutations altering protein charge and/or function in children of atomic bomb survivors: final report.探寻原子弹爆炸幸存者子女中改变蛋白质电荷和/或功能的突变：最终报告。
Am J Hum Genet. 1988 May;42(5):663-76.
3
Mortality in the children of atomic bomb survivors and controls.原子弹幸存者子女与对照组的死亡率。
Genetics. 1974 Feb;76(2):311-36. doi: 10.1093/genetics/76.2.311.
4
Cancer and non-cancer effects in Japanese atomic bomb survivors.日本原子弹幸存者中的癌症及非癌症影响。
J Radiol Prot. 2009 Jun;29(2A):A43-59. doi: 10.1088/0952-4746/29/2A/S04. Epub 2009 May 19.
5
Risk of death among children of atomic bomb survivors after 62 years of follow-up: a cohort study.追踪随访 62 年后原子弹幸存者子女的死亡风险：一项队列研究。
Lancet Oncol. 2015 Oct;16(13):1316-23. doi: 10.1016/S1470-2045(15)00209-0. Epub 2015 Sep 14.
6
Psychiatric sequelae in atomic bomb survivors in Hiroshima and Nagasaki two decades after the explosions.广岛和长崎原子弹爆炸二十年后幸存者的精神后遗症
Soc Psychiatry Psychiatr Epidemiol. 2002 Sep;37(9):409-15. doi: 10.1007/s00127-002-0572-5.
7
Radiation therapy among atomic bomb survivors, Hiroshima and Nagasaki.广岛和长崎原子弹爆炸幸存者中的放射治疗
Radiat Res. 1998 Jun;149(6):614-24.
8
Malignant tumors during the first 2 decades of life in the offspring of atomic bomb survivors.原子弹幸存者后代在生命最初20年期间的恶性肿瘤
Am J Hum Genet. 1990 Jun;46(6):1041-52.
9
Radiation dose-response relationships for thyroid nodules and autoimmune thyroid diseases in Hiroshima and Nagasaki atomic bomb survivors 55-58 years after radiation exposure.广岛和长崎原子弹爆炸幸存者在遭受辐射55 - 58年后甲状腺结节及自身免疫性甲状腺疾病的辐射剂量 - 反应关系。
JAMA. 2006 Mar 1;295(9):1011-22. doi: 10.1001/jama.295.9.1011.
引用本文的文献
1
Atomic bomb health benefits.原子弹的健康益处。
Dose Response. 2008;6(4):369-82. doi: 10.2203/dose-response.08-009.Luckey. Epub 2008 Aug 11.
2
Recovery of a low mutant frequency after ionizing radiation-induced mutagenesis during spermatogenesis.精子发生过程中电离辐射诱导诱变后低突变频率的恢复。
Mutat Res. 2008 Jul 31;654(2):150-7. doi: 10.1016/j.mrgentox.2008.05.012. Epub 2008 Jun 7.
3
Molecular relationships between closely related strains and species of nematodes.近缘线虫菌株和物种之间的分子关系。
J Mol Evol. 1981;18(1):18-23. doi: 10.1007/BF01733207.
4
5
Characterization of two new electrophoretic variants of human triosephosphate isomerase: stability, kinetic, and immunological properties.人磷酸丙糖异构酶两种新电泳变体的特性：稳定性、动力学及免疫学性质
Biochem Genet. 1982 Feb;20(1-2):59-76. doi: 10.1007/BF00484936.
6
De novo mutations producing unstable Hbs or Hbs M. II. Direct estimates of minimum nucleotide mutation rates in man.产生不稳定血红蛋白或血红蛋白M的新发突变。二、人类最小核苷酸突变率的直接估计。
Hum Genet. 1982;60(2):181-8. doi: 10.1007/BF00569709.
7
Assigning a probability for paternity in apparent cases of mutation.在明显的突变案例中确定父系概率。
Am J Hum Genet. 1981 Jul;33(4):617-28.
8
Electrophoretically detected germinal mutations induced in the mouse by ethylnitrosourea.电泳检测到的乙基亚硝基脲在小鼠中诱导产生的生殖细胞突变。
Proc Natl Acad Sci U S A. 1981 May;78(5):3138-41. doi: 10.1073/pnas.78.5.3138.
9
Is there a difference among human populations in the rate with which mutation produces electrophoretic variants?不同人群中突变产生电泳变异体的速率是否存在差异？
Proc Natl Acad Sci U S A. 1981 May;78(5):3108-12. doi: 10.1073/pnas.78.5.3108.
10
Rate of spontaneous mutation at human loci encoding protein structure.编码蛋白质结构的人类基因座的自发突变率。
Proc Natl Acad Sci U S A. 1980 Oct;77(10):6037-41. doi: 10.1073/pnas.77.10.6037.
本文引用的文献
1
A cohort-type study of survival in the children of parents exposed to atomic bombings.一项针对遭受原子弹轰炸的父母的子女的生存情况的队列研究。
Am J Hum Genet. 1966 Jul;18(4):339-73.
2
Radiation and the sex ratio in man.辐射与人类性别比例
Science. 1958 Aug 15;128(3320):343-8. doi: 10.1126/science.128.3320.343.
3
4
Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations.小鼠小染色体片段中功能单元的定义及其在解释辐射诱导突变性质中的应用。
Mutat Res. 1971 Jan;11(1):107-23. doi: 10.1016/0027-5107(71)90036-4.
5
Mortality in the children of atomic bomb survivors and controls.原子弹幸存者子女与对照组的死亡率。
Genetics. 1974 Feb;76(2):311-36. doi: 10.1093/genetics/76.2.311.
6
The incidence of rare alleles determining electrophoretic variants: data on 43 enzyme loci in man.决定电泳变异体的稀有等位基因的发生率：人类43个酶位点的数据。
Ann Hum Genet. 1974 Jan;37(3):237-53. doi: 10.1111/j.1469-1809.1974.tb01832.x.
7
Review of thirty years study of Hiroshima and Nagasaki atomic bomb survivors. II. Biological effects. B. Genetic effects. 2. Cytogenetic study.广岛和长崎原子弹幸存者三十年研究综述。II. 生物学效应。B. 遗传效应。2. 细胞遗传学研究。
J Radiat Res. 1975 Sep;16 Suppl:75-81. doi: 10.1269/jrr.16.supplement_75.
8
Physical dose estimates for A-bomb survivors. Studies at Chiba, Japan.
J Radiat Res. 1975 Sep;16 Suppl:12-23. doi: 10.1269/jrr.16.supplement_12.
9
A physical dose estimates for A-bomb survivors. Studies at Oak Ridge, U.S.A.
J Radiat Res. 1975 Sep;16 Suppl:1-11. doi: 10.1269/jrr.16.supplement_1.
10
Zotero 插件