Mohrenweiser H W, Neel J V
Am J Hum Genet. 1984 May;36(3):655-62.
Our previous studies have revealed a higher frequency of nonpolymorphic electrophoretic variants in blood samples from Amerindians than in similar samples from Caucasians and Japanese. Our present study finds, by contrast, that the frequency of deficiency variants of 11 erythrocyte enzymes, sampled in nine Amerindian tribes of Central and South America, is essentially the same (1.5/1,000 determinations) as in Caucasians or Japanese. Possible explanations of the elevated frequency of mobility variants in the tropical-zone/ unacculturated populations include: higher mutation rates resulting in both electrophoretic and activity variants in Amerindians but increased selection against deficiency variants in the Amerindians, or comparable mutation rates in both populations coupled with a greater probability of a mobility variant attaining a relatively high frequency among the Amerindians.
我们之前的研究表明，美洲印第安人血液样本中非多态性电泳变体的出现频率高于高加索人和日本人的类似样本。相比之下，我们目前的研究发现，在中美洲和南美洲的九个美洲印第安部落中采集的11种红细胞酶缺乏变体的频率，与高加索人或日本人基本相同（每1000次检测中有1.5例）。热带地区/未受文化影响人群中迁移率变体频率升高的可能解释包括：美洲印第安人较高的突变率导致电泳和活性变体都出现，但美洲印第安人对缺乏变体的选择增加；或者两个群体的突变率相当，但迁移率变体在美洲印第安人中达到相对高频率的可能性更大。
