Department of Radiotherapy and Radiation Oncology, University Medical Center Giessen and Marburg, Klinikstrasse, Giessen, Germany.
Institute of Medical Physics and Radiation Protection, University of Applied Sciences Giessen, Wiesenstrasse, Giessen, Germany.
J Appl Clin Med Phys. 2022 Nov;23(11):e13599. doi: 10.1002/acm2.13599. Epub 2022 Jul 25.
The aim of this study was to develop an algorithm that corrects the image of an electronic portal imaging device (EPID) of a linear accelerator so that it can be used for dosimetric purposes, such as in vivo dosimetry or quality assurance for photon radiotherapy. For that purpose, the impact of the field size, phantom thickness, and the varying spectral photon distribution within the irradiation field on the EPID image was investigated.
The EPID measurements were verified using reference measurements with ionization chambers. Therefore, absolute dose measurements with an ionization chamber and relative dose measurements with a detector array were performed. An EPID calibration and correction algorithm was developed to convert the EPID image to a dose distribution. The algorithm was validated by irradiating inhomogeneous phantoms using square fields as well as irregular IMRT fields.
It was possible to correct the influence of the field size, phantom thickness on the EPID signal as well as the homogenization of the image profile by several correction factors within 0.6%. A gamma index analysis (3%, 3 mm) of IMRT fields showed a pass rate of above 99%, when comparing to the planning system.
The developed algorithm enables an online dose measurement with the EPID during the radiation treatment. The algorithm is characterized by a robust, non-iterative, and thus real-time capable procedure with little measuring effort and does not depend on system-specific parameters. The EPID image is corrected by multiplying three independent correction factors. Therefore, it can easily be extent by further correction factors for other influencing variables, so it can be transferred to other linear accelerators and EPID configurations.
本研究旨在开发一种算法,以校正线性加速器电子射野影像装置(EPID)的图像,使其可用于剂量学目的,如体内剂量测定或光子放射治疗的质量保证。为此,研究了射野大小、体模厚度以及辐照野内光谱光子分布的变化对 EPID 图像的影响。
使用电离室进行参考测量验证了 EPID 测量。因此,进行了电离室的绝对剂量测量和探测器阵列的相对剂量测量。开发了一种 EPID 校准和校正算法,以将 EPID 图像转换为剂量分布。该算法通过用方形野和不规则调强放疗野照射不均匀体模进行了验证。
通过几个校正因子,可以将射野大小、体模厚度对 EPID 信号的影响以及图像轮廓的均匀化校正到 0.6%以内。对调强放疗野进行的伽马指数分析(3%,3mm)显示,与计划系统相比,通过率超过 99%。
所开发的算法使 EPID 能够在放射治疗过程中进行在线剂量测量。该算法的特点是具有稳健、非迭代且因此实时可行的程序,测量工作量小,并且不依赖于特定于系统的参数。通过乘以三个独立的校正因子校正 EPID 图像。因此,它可以很容易地通过进一步的校正因子扩展到其他影响变量,从而可以转移到其他线性加速器和 EPID 配置。