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与重度抑郁症症状严重程度和抗抑郁反应相关的血浆/IgG N-糖组学生物标志物。

Blood plasma/IgG N-glycome biosignatures associated with major depressive disorder symptom severity and the antidepressant response.

机构信息

Max Planck Institute of Psychiatry, Department of Translational Research in Psychiatry, 80804, Munich, Germany.

Genos Glycoscience Research Laboratory, Zagreb, Croatia.

出版信息

Sci Rep. 2018 Jan 9;8(1):179. doi: 10.1038/s41598-017-17500-0.

DOI:10.1038/s41598-017-17500-0
PMID:29317657
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5760622/
Abstract

While N-linked glycosylation has been extensively studied in the context of inflammatory and metabolic disorders, its relationship with major depressive disorder (MDD) and antidepressant treatment response has not been investigated. In our exploratory study, we analysed N-glycan profiles in blood plasma samples collected from MDD patients (n = 18) and found gender-dependent correlations with severity of depressive symptoms prior to initiating antidepressant treatment. In addition, several N-glycosylation traits showed gender-dependent associations with clinical antidepressant response. Follow up proteomics analysis in peripheral blood mononuclear cells (PBMCs) collected from MDD patients (n = 20) identified baseline and post-antidepressant treatment pathway differences between responder and non-responder patients. Reactome data analysis further delineated potential biological reaction differences between responder and non-responder patients. Our preliminary results suggest that specific glycosylation traits are associated with depressive symptom severity and antidepressant response and may be of use as biomarkers.

摘要

虽然 N-连接糖基化在炎症和代谢紊乱的背景下得到了广泛研究，但它与重度抑郁症（MDD）和抗抑郁治疗反应的关系尚未得到研究。在我们的探索性研究中，我们分析了来自 MDD 患者（n=18）的血浆样本中的 N-聚糖谱，并发现其与抗抑郁治疗前抑郁症状的严重程度存在性别依赖性相关性。此外，一些 N-糖基化特征与临床抗抑郁反应存在性别依赖性关联。对来自 MDD 患者的外周血单核细胞（PBMCs）（n=20）的随访蛋白质组学分析确定了应答者和非应答者患者之间的基线和抗抑郁治疗后途径差异。Reactome 数据分析进一步描绘了应答者和非应答者患者之间潜在的生物学反应差异。我们的初步结果表明，特定的糖基化特征与抑郁症状严重程度和抗抑郁反应相关，可能可用作生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff4/5760622/43e06425cee6/41598_2017_17500_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff4/5760622/523ba25eb366/41598_2017_17500_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff4/5760622/5e381834b168/41598_2017_17500_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff4/5760622/b81df7a94750/41598_2017_17500_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff4/5760622/f5f4c425cfe3/41598_2017_17500_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff4/5760622/ea3f7f7cf13c/41598_2017_17500_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff4/5760622/43e06425cee6/41598_2017_17500_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff4/5760622/523ba25eb366/41598_2017_17500_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff4/5760622/5e381834b168/41598_2017_17500_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff4/5760622/b81df7a94750/41598_2017_17500_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff4/5760622/f5f4c425cfe3/41598_2017_17500_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff4/5760622/ea3f7f7cf13c/41598_2017_17500_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff4/5760622/43e06425cee6/41598_2017_17500_Fig6_HTML.jpg

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