Department of Endocrinology and Internal Medicine, Aarhus University Hospital, 8000 Aarhus, Denmark.
Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
J Diabetes Res. 2017;2017:1249729. doi: 10.1155/2017/1249729. Epub 2017 Nov 26.
Mannan-binding lectin (MBL) concentration in plasma is increased in subjects with type 1 diabetes and associated with increased mortality and risk of diabetic nephropathy. Recent findings show that pancreas transplantation reduces MBL concentration. Whether the increased MBL concentration is reversed by improved glycaemic control remains unknown. We investigated the effects of improved glycaemic control on MBL concentration in patients with type 1 diabetes.
We measured MBL, fructosamine, and HbAat baseline and after 6 weeks in 52 type 1 diabetic patients following the change from conventional insulin therapy to insulin pump therapy.
After initiation of insulin pump therapy, the total daily insulin dose was significantly reduced (from 51 ± 18 IE/day to 39 ± 13 IE/day, < 0.0001). There was a significant decrease in HbA from 8.6% to 7.7% (from 70 mmol/mol to 61 mmol/mol, < 0.0001) and in fructosamine levels (from 356 mol/L to 311 mol/L, < 0.0001). MBL levels decreased by 10% from 2165 g/L (IQR 919-3389 g/L) at baseline to 1928 /L (IQR 811-2758 g/L) at follow-up ( = 0.005), but MBL change was not significantly correlated with changes in insulin dose, HbA, or fructosamine.
MBL concentration decreased following the initiation of insulin pump therapy in patients with type 1 diabetes and did not correlate with changes in glycaemic control.
1 型糖尿病患者血浆甘露聚糖结合凝集素（MBL）浓度升高，与死亡率增加和糖尿病肾病风险增加相关。最近的研究结果表明，胰腺移植可降低 MBL 浓度。血糖控制改善是否会逆转 MBL 浓度升高尚不清楚。我们研究了血糖控制改善对 1 型糖尿病患者 MBL 浓度的影响。
我们在 52 名接受常规胰岛素治疗改为胰岛素泵治疗的 1 型糖尿病患者中，测量了基线时和 6 周后的 MBL、果糖胺和 HbA1c。
开始胰岛素泵治疗后，总日胰岛素剂量显著减少（从 51±18IE/天降至 39±13IE/天， <0.0001）。HbA1c 从 8.6%降至 7.7%（从 70mmol/mol 降至 61mmol/mol， <0.0001），果糖胺水平也显著降低（从 356mol/L 降至 311mol/L， <0.0001）。MBL 水平从基线时的 2165g/L（IQR 919-3389g/L）下降 10%至随访时的 1928g/L（IQR 811-2758g/L）（ = 0.005），但 MBL 变化与胰岛素剂量、HbA1c 或果糖胺的变化无显著相关性。
1 型糖尿病患者开始胰岛素泵治疗后 MBL 浓度降低，与血糖控制变化无关。
