非侵入性1060纳米二极管激光用于腹部减脂的安全性和有效性
Safety and Efficacy of a Non-Invasive 1060 nm Diode Laser for Fat Reduction of the Abdomen.
作者信息
Bass Lawrence S, Doherty Sean T
出版信息
J Drugs Dermatol. 2018 Jan 1;17(1):106-112.
BACKGROUND
Changes in temperature are known to produce apoptosis in adipocytes. This study examines the use of a non-invasive treatment that applies 1060 nm laser energy transcutaneously to hyperthermically induce disruption of fat cells in the abdomen.
METHODS
Thirty-five subjects received application of 1060 nm laser on the abdomen for fat reduction. Ultrasound images and high-resolution two-dimensional photography were recorded at baseline, 6 weeks, and 12 weeks post treatment. Subjects maintained a stable diet and exercise routine throughout the course of the study. Weight was recorded at baseline and each follow-up visit. Three board certified dermatologists were trained as blinded evaluators and tasked with identifying before and after photographs from randomized, paired baseline, and 12-week photographs. Ultrasound images were used to measure the fat thickness change from baseline at 6 and 12 weeks. Level of patient satisfaction was graded at 12 weeks using a 6 point Likert scale.
REULTS
23% of subjects were Fitzpatrick IV-VI. Blinded evaluators correctly identified the post-treatment photograph 95% of the time (88%, 97%, and 100%). Mean reduction in fat layer thickness from baseline was statistically significant (P less than 0.001) at both 6 weeks (1.5 +/-1.23 mm) and 12 weeks (2.65 +/-1.41 mm). Mean weight change was +0.1 lb. Side effects were mild to moderate including edema, tenderness, and induration mostly resolving within 1-3 weeks post treatment. No serious adverse events were reported.
CONCLUSION
1060 nm based laser treatment can consistently reduce the fat contour in the abdomen with an excellent safety profile in all skin types. The study met all three of its prospectively defined endpoints of success.
J Drugs Dermatol. 2018;17(1):106-112.
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.背景
已知温度变化会导致脂肪细胞凋亡。本研究探讨一种非侵入性治疗方法，即经皮应用1060纳米激光能量，通过热效应诱导腹部脂肪细胞破坏。
方法
35名受试者接受腹部1060纳米激光减脂治疗。在基线、治疗后6周和12周记录超声图像和高分辨率二维照片。在研究过程中，受试者保持稳定的饮食和运动习惯。在基线和每次随访时记录体重。三名获得委员会认证的皮肤科医生接受培训成为盲法评估者，负责从随机、配对的基线照片和12周照片中识别治疗前后的照片。使用超声图像测量6周和12周时相对于基线的脂肪厚度变化。在12周时使用6点李克特量表对患者满意度进行评分。
结果
23%的受试者为菲茨帕特里克IV - VI型皮肤。盲法评估者在95%的情况下（88%、97%和100%）能正确识别治疗后的照片。在6周（1.5±1.23毫米）和12周（2.65±1.41毫米）时，相对于基线的脂肪层厚度平均减少具有统计学意义（P小于0.001）。平均体重变化为增加0.1磅。副作用为轻至中度，包括水肿、压痛和硬结，大多在治疗后1 - 3周内消退。未报告严重不良事件。
结论
基于1060纳米的激光治疗能够持续减少腹部脂肪轮廓，对所有皮肤类型均具有良好的安全性。该研究达到了其预先确定的所有三个成功终点。
《药物皮肤病学杂志》。2018年；17(1):106 - 112。
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