Gießen-Jung C, Wollenberg A, Reinholz M
Medizinische Klinik und Poliklinik III, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, München, Deutschland.
Klinik und Poliklinik für Dermatologie und Allergologie, Klinikum der Universität München, Ludwig-Maximilians-Universität München, München, Deutschland.
Internist (Berl). 2018 Feb;59(2):134-144. doi: 10.1007/s00108-017-0372-3.
The cutaneous manifestations of malignancies include nonmalignant skin disorders that occur in association with malignancies (facultative paraneoplastic dermatoses) and skin disorders that are always associated with hematologic diseases or solid tumors (obligate paraneoplastic dermatoses). Paraneoplastic increase of growth factors or immunological reactions lead to a variety of inflammatory, hyperkeratotic or proliferative skin reactions. When paraneoplastic dermatoses develop before cancer is diagnosed, recognition of these skin diseases can accelerate both the diagnosis and treatment. The presence of unexplained cutaneous findings should lead to a multidisciplinary evaluation of the patient. This manuscript summarizes the cutaneous manifestations associated with hematologic disorders and solid tumors, their localization and treatment options.
恶性肿瘤的皮肤表现包括与恶性肿瘤相关的非恶性皮肤疾病(兼性副肿瘤性皮肤病)以及总是与血液系统疾病或实体瘤相关的皮肤疾病(专性副肿瘤性皮肤病)。生长因子的副肿瘤性增加或免疫反应会导致各种炎症性、角化过度性或增殖性皮肤反应。当副肿瘤性皮肤病在癌症诊断之前出现时,认识到这些皮肤疾病可以加速诊断和治疗。出现无法解释的皮肤表现时,应促使对患者进行多学科评估。本文总结了与血液系统疾病和实体瘤相关的皮肤表现、其定位及治疗选择。