Schadt Courtney R
University of Louisville Division of Dermatology, Louisville, KY.
Semin Oncol. 2016 Jun;43(3):341-6. doi: 10.1053/j.seminoncol.2016.02.028. Epub 2016 Feb 23.
The skin is often the herald of an underlying systemic illness, and gastrointestinal malignancies can present in numerous ways in the skin. Paraneoplastic phenomenon, such as acanthosis nigricans and tripe palm, may be the first indicator of a gastrointestinal malignancy. In addition, gastrointestinal cancers can metastasize to the skin, as described in the well-known Sister Mary Joseph's nodule. Inflammatory systemic conditions such as dermatomyositis and multicentric reticulohistiocytosis can be associated with underlying malignancy. Finally, in numerous genetic syndromes with underlying malignancies, such as Muir-Torre, recognition of the skin signs leads to early diagnosis and screening.
皮肤常常是潜在全身性疾病的先兆，胃肠道恶性肿瘤可通过多种皮肤表现呈现出来。副肿瘤现象，如黑棘皮病和掌跖角化病，可能是胃肠道恶性肿瘤的首个指标。此外，胃肠道癌症可转移至皮肤，如著名的玛丽·约瑟夫修女结节所描述的那样。炎性全身性疾病，如皮肌炎和多中心网状组织细胞增生症，可能与潜在恶性肿瘤相关。最后，在众多伴有潜在恶性肿瘤的遗传综合征中，如穆尔-托雷综合征，识别皮肤体征可实现早期诊断和筛查。
