Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg Essen, Hufelandstrasse 55, 45122, Essen, Germany.
Eur Radiol. 2018 Jun;28(6):2273-2280. doi: 10.1007/s00330-017-5243-8. Epub 2018 Jan 10.
The aim of this study was to investigate the radiation dose and image quality of a whole-body low-dose CT (WBLDCT) using spectral shaping at 100 kV (Sn 100 kV) for the assessment of osteolytic lesions in patients with multiple myeloma.
Thirty consecutive patients were retrospectively selected, who underwent a WBLDCT on a third-generation dual-source CT (DSCT) (Sn 100 kV, ref. mAs: 130). They were matched with patients, who were examined on a second-generation DSCT with a standard low-dose protocol (100 kV, ref. mAs: 111). Objective and subjective image quality, radiation exposure as well as the frequency of osteolytic lesions were evaluated.
All scans were of diagnostic image quality. Subjective overall image quality was significantly higher in the study group (p = 0.0003). Objective image analysis revealed that signal intensities, signal-to-noise ratio and contrast-to-noise ratio of the bony structures were equal or significantly higher in the control group. There was no significant difference in the frequency of osteolytic lesions (p = 0.259). The median effective dose of the study protocol was significantly lower (1.45 mSv vs. 5.65 mSv; p < 0.0001).
WBLDCT with Sn 100 kV can obtain sufficient image quality for the depiction of osteolytic lesions while reducing the radiation dose by approximately 74%.
• Spectral shaping using tin filtration is beneficial for whole-body low-dose CT • Sn 100 kV yields sufficient image quality for depiction of osteolytic lesions • Whole-body low-dose CT can be performed with a median dose of 1.5 mSv.
本研究旨在探讨使用 100kV 能谱曲线（Sn100kV）行全身低剂量 CT（WBLDCT）对多发性骨髓瘤溶骨性病变的评估中的辐射剂量和图像质量。
回顾性选择了 30 例连续患者，这些患者在第三代双源 CT（DSCT）（Sn100kV，参考 mAs：130）上进行了 WBLDCT。这些患者与在第二代 DSCT 上进行标准低剂量方案（100kV，参考 mAs：111）的患者相匹配。评估了客观和主观的图像质量、辐射暴露以及溶骨性病变的频率。
所有扫描均具有诊断图像质量。研究组的主观总体图像质量显著更高（p = 0.0003）。客观图像分析显示，骨结构的信号强度、信噪比和对比噪声比在对照组中相等或显著更高。溶骨性病变的频率无显著差异（p = 0.259）。研究方案的中位有效剂量显著更低（1.45mSv 与 5.65mSv；p < 0.0001）。
Sn100kV 的 WBLDCT 可以获得足够的图像质量来描绘溶骨性病变，同时将辐射剂量降低约 74%。
• 锡滤过的能谱成形对全身低剂量 CT 有益• Sn100kV 可产生足以描绘溶骨性病变的图像质量• 全身低剂量 CT 可在中位数剂量为 1.5mSv 时进行。
