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六种亚麻籽品种木质素丰富部分的抗癌潜力。

Anticancer potentiality of lignan rich fraction of six Flaxseed cultivars.

机构信息

Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El-Einy Street, Cairo, 11562, Egypt.

Department of Pharmacognosy, Faculty of Pharmacy, October University for Modern Science and Arts (MSA), 12566, 6th October, Egypt.

出版信息

Sci Rep. 2018 Jan 11;8(1):544. doi: 10.1038/s41598-017-18944-0.

DOI:10.1038/s41598-017-18944-0
PMID:29323210
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5764973/
Abstract

The objective of our study is to highlight the therapeutic effect and mechanism of action by which purified Flaxseed hydrolysate (PFH) which is a lignan rich fraction exerts its anticancer activity on a human breast cancer cell line (T47D) and in mice bearing tumor. HPLC analysis of PFH of six flaxseed cultivars had shown that PFH of the cultivar Giza 9 (PFH-G9) contains the highest concentration of SDG (81.64 mg/g). The in vitro cytotoxic potentiality of PFH's of six flaxseed cultivars was screened against a panel of human cancer cell lines. PFH -G9 showed the most significant cytotoxic activity against ER-receptor positive breast cell lines MCF7 and T47D with IC 13.8 and 15.8 µg/ml, respectively. Moreover, PFH-G9 reduced the expression of the metastasis marker, 1-α, metalloproteinases and vascular endothelial growth factor (VEGF), one of the most potent stimulators of angiogenesis, while it increased the caspase-3 dependent apoptosis. Our study also showed that dietary intake of 10% of Giza 9 Flaxseeds (FS), fixed oil (FSO) or Flax meal (FSM) twice daily for 3 weeks in mice-bearing solid Ehrlich ascites carcinoma (EAC) resulted in reducing the tumor volume, the expression of estrogen, insulin growth factor, progesterone, VEGF and MMP-2, but enhanced expression of caspase-3.

摘要

我们的研究目的是强调亚麻籽水解产物（PFH）的治疗效果和作用机制，这种富含木脂素的成分对人乳腺癌细胞系（T47D）和荷瘤小鼠发挥抗癌活性。对六种亚麻籽品种的 PFH 的 HPLC 分析表明，吉萨 9 号（PFH-G9）品种的 PFH 含有最高浓度的 SDG（81.64mg/g）。六种亚麻籽品种的 PFH 的体外细胞毒性潜力在一组人类癌细胞系中进行了筛选。PFH-G9 对 ER 受体阳性乳腺癌细胞系 MCF7 和 T47D 表现出最显著的细胞毒性活性，IC 13.8 和 15.8µg/ml。此外，PFH-G9 降低了转移标记物、1-α、金属蛋白酶和血管内皮生长因子（VEGF）的表达，VEGF 是血管生成最有力的刺激物之一，同时它增加了依赖半胱氨酸天冬氨酸蛋白酶-3 的细胞凋亡。我们的研究还表明，在荷实体 Ehrlich 腹水癌（EAC）的小鼠中，每日两次摄入 10%的吉萨 9 亚麻籽（FS）、固定油（FSO）或亚麻粉（FSM），连续 3 周，可减少肿瘤体积、雌激素、胰岛素生长因子、孕酮、VEGF 和 MMP-2 的表达，但增强了半胱氨酸天冬氨酸蛋白酶-3 的表达。

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