Dunk A A, Jenkins W J, Burroughs A K, Walt R P, Osuafor T O, Sherlock S, Mackie S, Dick R
Br J Clin Pharmacol. 1983 Aug;16(2):117-20. doi: 10.1111/j.1365-2125.1983.tb04973.x.
Since hepatic clearance of ICG is reduced by H2-receptor antagonists in normal subjects, it has been suggested that they reduce liver blood flow. We have studied the effect of intravenous ranitidine on ICG clearance in twelve patients with chronic liver disease. Wedged and free hepatic venous pressure were measured before and after intravenous ranitidine in nine of the patients, and the hepatic extraction of ICG was determined in six patients. ICG clearance fell by 22 +/- 11% (s.e. mean) 60 min after ranitidine. In patients in whom ICG clearance fell after intravenous ranitidine the hepatic extraction of ICG was also reduced. There was no significant change in the gradient between wedged and free hepatic venous pressure after ranitidine. It is therefore unlikely that ranitidine lowers liver blood flow.
由于在正常受试者中H2受体拮抗剂会降低吲哚菁绿（ICG）的肝清除率，因此有人认为它们会减少肝血流量。我们研究了静脉注射雷尼替丁对12例慢性肝病患者ICG清除率的影响。对9例患者在静脉注射雷尼替丁前后测量了肝楔压和自由肝静脉压，并对6例患者测定了ICG的肝摄取率。雷尼替丁注射60分钟后，ICG清除率下降了22±11%（标准误均值）。在静脉注射雷尼替丁后ICG清除率下降的患者中，ICG的肝摄取率也降低了。雷尼替丁注射后肝楔压和自由肝静脉压之间的梯度没有显著变化。因此，雷尼替丁不太可能降低肝血流量。
