Gin W, Kay A B
J Allergy Clin Immunol. 1985 Nov;76(5):675-82. doi: 10.1016/0091-6749(85)90670-0.
The expression of IgG (Fc) receptor (FcR) and complement receptor (CR) on peripheral blood monocytes and neutrophils was determined by the rosette technique in patients with asthma receiving different forms of treatment. In 31 patients taking inhaled therapy (i.e., bronchodilators alone or in combination with inhaled corticosteroids), monocyte FcR (48.19 +/- 1.24%, mean +/- SEM) and complement (66.54 +/- 1.09%) rosettes were significantly higher (FcR p less than 0.001, CR p less than 0.001) than in the 17 healthy, normal control subjects (FcR 37.94 +/- 0.82%, CR 59.7 +/- 0.98%). These increases in the percent rosettes between the two groups were observed even when a wide concentration range of IgG or complement was used to coat the red cells. No significant differences in monocyte receptor expression were observed between those patients being treated with bronchodilators alone or patients being treated in combination with inhaled corticosteroids. In 19 patients with asthma receiving oral corticosteroids, the mean monocyte FcR (38.21 +/- 1.73%) and CR (52.78 +/- 2.09%) were significantly reduced when these patients were compared with those patients receiving inhaled therapy alone (FcR p less than 0.001, CR p less than 0.001), and there was a significant inverse correlation between the percent rosettes and the dose of prednisolone. Neutrophil CR (51.32 +/- 1.30%, p less than 0.05) but not FcR expression (24.7 +/- 0.80%) was significantly increased when these were compared with those of control subjects (FcR 24.7 +/- 0.60%, CR 47.11 +/- 0.86%), and both neutrophil FcR and CR expression was significantly reduced (FcR p less than 0.01, CR p less than 0.001) in those patients with asthma receiving oral corticosteroids. (ABSTRACT TRUNCATED AT 250 WORDS)
采用玫瑰花结技术测定了接受不同治疗方式的哮喘患者外周血单核细胞和中性粒细胞上IgG（Fc）受体（FcR）和补体受体（CR）的表达。在31例接受吸入治疗（即单独使用支气管扩张剂或与吸入性糖皮质激素联合使用）的患者中，单核细胞FcR（48.19±1.24%，均值±标准误）和补体玫瑰花结（66.54±1.09%）显著高于17名健康正常对照者（FcR 37.94±0.82%，CR 59.7±0.98%）（FcR p<0.001，CR p<0.001）。即使使用宽浓度范围的IgG或补体包被红细胞，两组间玫瑰花结百分比的这些增加仍可观察到。单独使用支气管扩张剂治疗的患者与吸入性糖皮质激素联合治疗的患者之间，单核细胞受体表达无显著差异。在19例接受口服糖皮质激素治疗的哮喘患者中，与仅接受吸入治疗的患者相比，单核细胞FcR均值（38.21±1.73%）和CR均值（52.78±2.09%）显著降低（FcR p<0.001，CR p<0.001），玫瑰花结百分比与泼尼松龙剂量之间存在显著负相关。与对照者相比，中性粒细胞CR（51.32±1.30%，p<0.05）但FcR表达（24.7±0.80%）无显著增加（FcR 24.7±0.60%，CR 47.11±0.86%），在接受口服糖皮质激素治疗的哮喘患者中，中性粒细胞FcR和CR表达均显著降低（FcR p<0.01，CR p<0.001）。（摘要截断于250字）
