Kim Jooyoung, Lee Joohyung
Sport, Health and Rehabilitation Major, College of Physical Education, Kookmin University, Seoul, Korea.
J Exerc Rehabil. 2017 Dec 27;13(6):621-626. doi: 10.12965/jer.1735072.536. eCollection 2017 Dec.
High-intensity eccentric muscle contraction induces muscle damage. Damaged muscles recover through different processes, including degeneration, inflammation, regeneration, and fibrosis; some of these processes are mediated through the actions of cytokines. The transforming growth factor-beta (TGF-β) is one such cytokine involved in muscle recovery and repair. In this regard, TGF-β regulates the skeletal muscle inflammatory response, inhibits muscle regeneration, regulates extracellular matrix remodeling, and promotes fibrosis. Although some studies have suggested that inhibition of TGF-β after muscle damage promotes muscle regeneration and recovery, other studies have noted that TGF-β inhibition actually reduces muscle strength because it leads to incomplete muscle regeneration. Despite the importance of TGF-β in the repair of damaged muscles, most studies have focused on examining its role in muscle diseases such as chronic inflammatory diseases or Duchenne's muscular dystrophy. Here, we have reviewed the existing literature for examining the role of TGF-β in muscle damage and regeneration after eccentric muscle contraction.
高强度离心性肌肉收缩会导致肌肉损伤。受损肌肉通过不同过程恢复，包括变性、炎症、再生和纤维化；其中一些过程由细胞因子介导。转化生长因子-β（TGF-β）就是这样一种参与肌肉恢复和修复的细胞因子。在这方面，TGF-β调节骨骼肌炎症反应，抑制肌肉再生，调节细胞外基质重塑，并促进纤维化。尽管一些研究表明，肌肉损伤后抑制TGF-β可促进肌肉再生和恢复，但其他研究指出，TGF-β抑制实际上会降低肌肉力量，因为它会导致肌肉再生不完全。尽管TGF-β在受损肌肉修复中很重要，但大多数研究都集中在研究其在慢性炎症性疾病或杜氏肌营养不良等肌肉疾病中的作用。在这里，我们回顾了现有文献，以研究TGF-β在离心性肌肉收缩后肌肉损伤和再生中的作用。
