School of Life Science, Tsinghua University, Beijing 100084, China; Suzhou Joekai Biotech LLC, Kunshan City, Jiangsu, 215300, China.
Suzhou Joekai Biotech LLC, Kunshan City, Jiangsu, 215300, China.
Chin J Nat Med. 2017 Dec;15(12):899-904. doi: 10.1016/S1875-5364(18)30005-0.
Herbal extracts have been extensively used worldwide for their application on memory improvement, especially among aged and memory-deficit populations. In the present study, the memory loss induced by human Abeta protein over-expression in fruitfly Alzheimer's disease (AD) model was rescued by multiple extracts from Gardenia jasminoides. Three extracts that rich with gardenia yellow, geniposide, and gardenoside components showed distinct rescue effect on memory loss. Further investigation on adding gardenoside into a formula of Ganoderma lucidum, Panax notoginseng and Panax ginseng (GPP) also support its therapeutic effects on memory improvement. Interestingly, the application of GPP and gardenoside did not alter the accumulation of Abeta proteins but suppressed the expression of immune-related genes in the brain. These results revealed the importance and relevancy of anti-inflammation process and the underlying mechanisms on rescuing memory deficits, suggesting the potential therapeutic use of the improved GPP formulation in improving cognition in defined population in the future.
草药提取物在全球范围内被广泛用于改善记忆，尤其是在老年人和记忆缺陷人群中。在本研究中，通过从栀子中提取的多种提取物，挽救了果蝇阿尔茨海默病（AD）模型中人类 Abeta 蛋白过表达引起的记忆丧失。三种富含栀子黄、京尼平苷和栀子苷成分的提取物对记忆丧失有明显的挽救作用。进一步研究将栀子苷加入灵芝、三七和人参（GPP）的配方中，也支持其改善记忆的治疗效果。有趣的是，GPP 和栀子苷的应用并没有改变 Abeta 蛋白的积累，而是抑制了大脑中免疫相关基因的表达。这些结果揭示了抗炎过程的重要性和相关性，以及挽救记忆缺陷的潜在机制，表明改良 GPP 配方在未来针对特定人群改善认知方面具有潜在的治疗用途。
