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本文引用的文献

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Acquisition of Clostridium difficile Colonization and Infection After Transfer From a Veterans Affairs Hospital to an Affiliated Long-Term Care Facility.从退伍军人事务医院转入附属医院长期护理机构后艰难梭菌定植和感染的获得。
Infect Control Hosp Epidemiol. 2017 Sep;38(9):1070-1076. doi: 10.1017/ice.2017.140. Epub 2017 Jul 11.
2
Effects of control interventions on Clostridium difficile infection in England: an observational study.英格兰控制干预措施对艰难梭菌感染的影响：一项观察性研究。
Lancet Infect Dis. 2017 Apr;17(4):411-421. doi: 10.1016/S1473-3099(16)30514-X. Epub 2017 Jan 25.
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Effect of a national 4C antibiotic stewardship intervention on the clinical and molecular epidemiology of Clostridium difficile infections in a region of Scotland: a non-linear time-series analysis.国家 4C 抗生素管理干预对苏格兰某地区艰难梭菌感染的临床和分子流行病学的影响：非线性时间序列分析。
Lancet Infect Dis. 2017 Feb;17(2):194-206. doi: 10.1016/S1473-3099(16)30397-8. Epub 2016 Nov 4.
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Estimating National Trends in Inpatient Antibiotic Use Among US Hospitals From 2006 to 2012.估算2006年至2012年美国医院住院患者抗生素使用的全国趋势。
JAMA Intern Med. 2016 Nov 1;176(11):1639-1648. doi: 10.1001/jamainternmed.2016.5651.
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Changing epidemiology of Clostridium difficile infection following the introduction of a national ribotyping-based surveillance scheme in England.在英国引入基于核糖体分型的全国监测计划后，艰难梭菌感染的流行病学发生变化。
Clin Infect Dis. 2012 Oct;55(8):1056-63. doi: 10.1093/cid/cis614. Epub 2012 Jul 11.
6
Decrease of hypervirulent Clostridium difficile PCR ribotype 027 in the Netherlands.荷兰产强毒型艰难梭菌 PCR 核糖型 027 减少。
Euro Surveill. 2009 Nov 12;14(45):19402. doi: 10.2807/ese.14.45.19402-en.
7
Comparison of seven techniques for typing international epidemic strains of Clostridium difficile: restriction endonuclease analysis, pulsed-field gel electrophoresis, PCR-ribotyping, multilocus sequence typing, multilocus variable-number tandem-repeat analysis, amplified fragment length polymorphism, and surface layer protein A gene sequence typing.七种艰难梭菌国际流行菌株分型技术的比较：限制性内切酶分析、脉冲场凝胶电泳、PCR核糖体分型、多位点序列分型、多位点可变数目串联重复分析、扩增片段长度多态性以及表层蛋白A基因序列分型。
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2011-2015 年美国 10 个地区长期护理机构发病艰难梭菌感染的趋势。

Trends in incidence of long-term-care facility onset Clostridium difficile infections in 10 US geographic locations during 2011-2015.

机构信息

Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA.

Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA.

出版信息

Am J Infect Control. 2018 Jul;46(7):840-842. doi: 10.1016/j.ajic.2017.11.026. Epub 2018 Jan 9.

DOI:10.1016/j.ajic.2017.11.026
PMID:29329918
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6489441/
Abstract

During 2011-2015, the adjusted long-term-care facility onset Clostridium difficile infection incidence rate in persons aged ≥65 years decreased annually by 17.45% (95% confidence interval, 14.53%-20.43%) across 10 US sites. A concomitant decline in inpatient fluoroquinolone use and the C difficile epidemic strain NAP1/027 among persons aged ≥65 years may have contributed to the decrease in long-term-care facility-onset C difficile infection incidence rate.

摘要

在 2011 年至 2015 年期间，美国 10 个地点≥65 岁人群的长期护理机构中，调整后的艰难梭菌感染发生率每年下降 17.45%（95%置信区间，14.53%-20.43%）。≥65 岁人群中住院氟喹诺酮类药物使用和艰难梭菌流行株 NAP1/027 的同时减少可能导致长期护理机构中艰难梭菌感染发生率的下降。