Chávez E, Briones R, Michel B, Bravo C, Jay D
Arch Biochem Biophys. 1985 Nov 1;242(2):493-7. doi: 10.1016/0003-9861(85)90235-8.
The effect of cadmium on some functions of mitochondria isolated from kidneys of rat was studied. Addition of cadmium chloride to mitochondria induced stimulation of both State 4 respiratory rate and ATPase activity, which are prevented by the addition of ruthenium red. We also show that cadmium inhibits competitively calcium translocation; this inhibitory effect of cadmium is reverted by the addition of dithiothreitol. From these results, it is proposed that, similarly to Ca2+, cadmium penetrates mitochondria and binds to a membrane dithiol group, which is essential for the translocation of the cation.
研究了镉对从大鼠肾脏分离的线粒体某些功能的影响。向线粒体中添加氯化镉会诱导状态4呼吸速率和ATP酶活性的刺激，而添加钌红可阻止这种刺激。我们还表明，镉竞争性抑制钙转运；添加二硫苏糖醇可逆转镉的这种抑制作用。从这些结果推测，与Ca2+类似，镉穿透线粒体并与膜二硫醇基团结合，该基团对于阳离子转运至关重要。
