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探讨具有广泛自闭症谱系特征和自闭症谱系障碍及神经性厌食症的青少年和年轻成人的临床结局:一项多中心研究。

An examination of the clinical outcomes of adolescents and young adults with broad autism spectrum traits and autism spectrum disorder and anorexia nervosa: A multi centre study.

机构信息

Institute of Psychiatry-Federal University of Rio de Janeiro (IPUB-UFRJ), Rio de Janeiro, Brazil.

Department of Psychology, University of Alberta, Edmonton, Alberta, Canada.

出版信息

Int J Eat Disord. 2018 Feb;51(2):174-179. doi: 10.1002/eat.22823. Epub 2018 Jan 13.

DOI:10.1002/eat.22823
PMID:29331075
Abstract

OBJECTIVES

To compare the clinical outcomes of adolescents and young adults with anorexia nervosa (AN) comorbid with broad autism spectrum disorder (ASD) or ASD traits.

METHOD

The developmental and well-being assessment and social aptitude scale were used to categorize adolescents and young adults with AN (N = 149) into those with ASD traits (N = 23), and those who also fulfilled diagnostic criteria for a possible/probable ASD (N = 6). We compared both eating disorders specific measures and broader outcome measures at intake and 12 months follow-up.

RESULTS

Those with ASD traits had significantly more inpatient/day-patient service use (p = .015), as well as medication use (p < .001) at baseline. Both groups had high social difficulties and poorer global functioning (strengths and difficulties questionnaire) at baseline, which improved over time but remained higher at 12 months in the ASD traits group (p = .002). However, the improvement in eating disorder symptoms at 12 months was similar between groups with or without ASD traits. Treatment completion rates between AN only and ASD traits were similar (80.1 vs. 86.5%).

DISCUSSION

Adolescents with AN and ASD traits show similar reductions in their eating disorder symptoms. Nevertheless, their social difficulties remain high suggesting that these are life-long difficulties rather than starvation effects.

摘要

目的

比较伴有广泛自闭症谱系障碍(ASD)或 ASD 特征的青少年和年轻成人厌食症(AN)患者的临床结局。

方法

采用发育和健康评估及社交能力量表,将患有 AN 的青少年和年轻成人(N=149)分为具有 ASD 特征(N=23)和同时符合可能/可能 ASD 诊断标准的患者(N=6)。我们比较了两组患者在入组时和 12 个月随访时的特定饮食障碍评估和更广泛的结果评估。

结果

具有 ASD 特征的患者在基线时的住院/日间患者服务使用(p=0.015)和药物使用(p<0.001)明显更多。两组患者在基线时都存在严重的社交困难和较差的整体功能(优势与困难问卷),但随着时间的推移逐渐改善,但在 ASD 特征组中仍在 12 个月时较高(p=0.002)。然而,两组患者的饮食障碍症状在 12 个月时的改善程度相似。仅患有 AN 和具有 ASD 特征的患者之间的治疗完成率相似(80.1% vs. 86.5%)。

讨论

患有 AN 和 ASD 特征的青少年患者的饮食障碍症状相似减少。然而,他们的社交困难仍然很高,表明这些是终身的困难,而不是饥饿的影响。

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