Division of General Pediatrics and Adolescent Health, University of Minnesota, USA.
College of Public Health, The Ohio State University, USA; Comprehensive Cancer Center, The Ohio State University, USA.
Vaccine. 2018 Dec 18;36(52):8158-8164. doi: 10.1016/j.vaccine.2018.01.009. Epub 2018 Jan 10.
Effective interventions to promote human papillomavirus (HPV) vaccination are needed, particularly among populations at increased risk of HPV-related disease. We developed and pilot tested a web-based intervention, Outsmart HPV, to promote HPV vaccination among young gay and bisexual men (YGBM).
In 2016, we recruited a national sample (n = 150) of YGBM ages 18-25 in the United States who had not received any doses of HPV vaccine. Participants were randomized to receive either standard HPV vaccination information (control) or population-targeted, individually-tailored content (Outsmart HPV intervention). We assessed between group differences in HPV vaccination attitudes and beliefs immediately following the intervention using multiple linear regression.
There were no differences in HPV vaccination attitudes, beliefs and intentions between groups at baseline. Compared to participants in the control group, intervention participants reported: greater perception that men who have sex with men are at higher risk for anal cancer relative to other men (b = 0.34); greater HPV vaccination self-efficacy (b = 0.15); and fewer perceived harms of HPV vaccine (b = -0.34) on posttest surveys (all p < .05). Overall, intervention participants reported high levels of acceptability and satisfaction with the Outsmart HPV intervention (all > 4.4 on a 5-point scale).
Findings from this study provide preliminary support for a brief, tailored web-based intervention in improving HPV vaccination attitudes and beliefs among YGBM. An important next step is to determine the effects of Outsmart HPV on HPV vaccine uptake.
ClinicalTrials.gov identifier NCT02835755.
需要有效的干预措施来促进人乳头瘤病毒（HPV）疫苗接种，尤其是在HPV 相关疾病风险增加的人群中。我们开发并试点测试了一个基于网络的干预措施，名为“智胜 HPV”，以促进年轻男同性恋和双性恋者（YGBM）接种 HPV 疫苗。
2016 年，我们招募了来自美国的 150 名年龄在 18-25 岁之间、尚未接种任何剂量 HPV 疫苗的 YGBM 作为研究对象。参与者被随机分配接受标准 HPV 疫苗接种信息（对照组）或针对特定人群、量身定制的内容（Outsmart HPV 干预组）。我们使用多元线性回归评估干预后两组之间 HPV 疫苗接种态度和信念的差异。
在基线时，两组之间 HPV 疫苗接种态度、信念和意图没有差异。与对照组参与者相比，干预组参与者报告：认为男男性行为者比其他男性更容易患肛门癌的风险更高（b=0.34）；HPV 疫苗接种自我效能感更高（b=0.15）；认为 HPV 疫苗的感知危害更小（b=-0.34），这些差异在测试后调查中均有体现（所有 p 值均<0.05）。总体而言，干预组参与者对“智胜 HPV”干预措施的接受度和满意度均很高（所有项目的评分均>4.4，满分 5 分）。
本研究结果初步支持了一种简短的、个性化的基于网络的干预措施，可以改善 YGBM 对 HPV 疫苗接种的态度和信念。下一步的重要步骤是确定“智胜 HPV”对 HPV 疫苗接种率的影响。
ClinicalTrials.gov 标识符 NCT02835755。
