Choi Ra-Yeong, Ham Ju Ri, Yeo Jiyoung, Hur Jae-Seoun, Park Seok-Kyu, Kim Myung-Joo, Lee Mi-Kyung
Department of Food and Nutrition, Sunchon National University, Jeonnam 57922, Korea.
Department of Environmental Education, Sunchon National University, Jeonnam 57922, Korea.
Prev Nutr Food Sci. 2017 Dec;22(4):285-292. doi: 10.3746/pnf.2017.22.4.285. Epub 2017 Dec 31.
(TV) is an edible lichen that is prevalent in the alpine zone of East Asia. This study evaluated the feasibility of using TV acetone extracts as a functional food based on experiments using cell line and obese mice. The cellular triglyceride levels and Oil red O staining of 3T3-L1 cells indicated that TV extracts (5 and 10 μg/mL) dose-dependently suppressed adipocyte differentiation and lipid accumulation compared with the control. The TV extract (0.4%, w/w) in a high-fat diet (HFD) was supplemented to C57BL/6N mice for 12 weeks, and TV extract supplement significantly reduced visceral fat mass and body weight compared with HFD feeding alone. The TV extract also induced significant decreases in serum and hepatic lipids, whereas it increased the serum high-density lipoproteins-cholesterol/total cholesterol ratio and fecal lipids levels. Moreover, the TV extract led to significantly lower homeostasis model assessment of insulin resistance in diet-induced obese mice. Taken together, these results suggest that the TV extract may have anti-obesity effects, including lipid-lowering, and it is a natural resource with the potential for use in obesity management.
松萝是一种可食用地衣，在东亚高寒地区很常见。本研究基于细胞系实验和肥胖小鼠实验，评估了松萝丙酮提取物作为功能性食品的可行性。3T3-L1细胞的细胞甘油三酯水平和油红O染色表明，与对照组相比，松萝提取物（5和10μg/mL）呈剂量依赖性地抑制脂肪细胞分化和脂质积累。将高脂饮食（HFD）中添加松萝提取物（0.4%，w/w）喂养C57BL/6N小鼠12周，与单独喂养HFD相比，补充松萝提取物显著降低了内脏脂肪量和体重。松萝提取物还显著降低了血清和肝脏脂质水平，同时提高了血清高密度脂蛋白胆固醇/总胆固醇比值和粪便脂质水平。此外，松萝提取物使饮食诱导的肥胖小鼠的胰岛素抵抗稳态模型评估值显著降低。综上所述，这些结果表明松萝提取物可能具有抗肥胖作用，包括降脂作用，是一种有潜力用于肥胖管理的天然资源。
