Licitra C M, Brooks R G, Sieger B E
Antimicrob Agents Chemother. 1987 May;31(5):805-7. doi: 10.1128/AAC.31.5.805.
The clinical efficacy of ciprofloxacin was evaluated with 21 patients with soft tissue infection due mainly to gram-negative aerobic bacteria. Clinical cure was noted in 16 patients (76%), and clinical improvement was noted in the remaining 5 patients (24%). In addition, levels of ciprofloxacin were measured in the sera and tissues of 11 patients. Mean concentrations in tissue averaged 1.75 times the levels in serum. Ciprofloxacin should provide serum and soft tissue concentrations above the MICs for most gram-negative aerobic bacteria.
对21例主要由革兰氏阴性需氧菌引起的软组织感染患者评估了环丙沙星的临床疗效。16例患者（76%）实现临床治愈，其余5例患者（24%）有临床改善。此外，还对11例患者的血清和组织中环丙沙星水平进行了测定。组织中的平均浓度平均为血清浓度的1.75倍。环丙沙星对大多数革兰氏阴性需氧菌应能提供高于其最低抑菌浓度的血清和软组织浓度。
