Gao Li, Fan Yi-Zeng, Zhang Tao-Hong, Xu Hui-Qiu, Zeng Xian-Ling, Hou Tao, Dan Wei-Chao, Zeng Jin, An Rui-Fang
Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Xi'an Jiaotong University, Health Science Center, Xi'an Jiaotong University Xi'an Shaanxi 710061 P. R. China
Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Health Science Center, Xi'an Jiaotong University Xi'an Shaanxi 710061 P. R. China
RSC Adv. 2019 Apr 12;9(20):11567-11575. doi: 10.1039/c9ra01029g. eCollection 2019 Apr 9.
MoSe is a typical transition-metal dichalcogenide material, and many researches have been focused on using its property of near infrared strong absorption for laser mediated photothermal cancer treatment. However, the anti-canter effect of MoSe and its possible mechanism in renal cell carcinoma (RCC) is still unclear. RCC has high incidence of metastasis, which is known as one of the most lethal malignancies in the urological system. This study revealed that the carbon-doped MoSe particles can obviously inhibit proliferation for 786-O and ACHN cells. Meanwhile, the carbon-doped MoSe nanoparticles have little impact on the viability of KH-2 cells . The mechanism analysis revealed that the carbon-doped MoSe particles have hydrogen bond effect in aqueous solution, and the particle aggregation effect caused the KH-2 cells to have high viability. The carbon-doped MoSe nanoparticles with minimal toxicity may be a potential therapeutic candidate against RCC.
二硒化钼（MoSe）是一种典型的过渡金属二硫属化物材料，许多研究都集中在利用其近红外强吸收特性进行激光介导的光热癌症治疗。然而，MoSe在肾细胞癌（RCC）中的抗癌作用及其可能的机制仍不清楚。RCC转移发生率高，是泌尿系统中最致命的恶性肿瘤之一。本研究表明，碳掺杂的MoSe颗粒能明显抑制786 - O和ACHN细胞的增殖。同时，碳掺杂的MoSe纳米颗粒对KH - 2细胞的活力影响很小。机制分析表明，碳掺杂的MoSe颗粒在水溶液中具有氢键作用，颗粒聚集效应导致KH - 2细胞具有较高的活力。毒性最小的碳掺杂MoSe纳米颗粒可能是一种潜在的抗RCC治疗候选物。
