Wang Ya-Li, Zhang Lin, Li Meng-Yan, Wang Li-Wei, Ma Chao-Mei
a College of Life Sciences , Inner Mongolia University , Huhhot , China.
b MOE Key Laboratory of Bioinformatics, School of Life Science , Tsinghua University , Beijing , China.
Nat Prod Res. 2019 Jun;33(11):1550-1555. doi: 10.1080/14786419.2017.1423305. Epub 2018 Jan 15.
Two lignans including a new one, five flavonoids and five coumarins were isolated from the whole plant of (synonymised as Makino). The new compound was structurally determined as (7,8,8') -3,3'-dimethoxy- 4,4',9-trihydroxy- 7,9'-epoxy-8,8'-lignan 9-O-rutinoside by analysis of its NMR, MS and CD spectroscopic data. The known compounds were characterised by comparing their NMR and MS data with those reported. Among the known compounds, 5-hydroxy-4'-methoxyflavone-7-O- rutinoside, 6,7-di-O-β-D- glucopyranosylesculetin, and 7,8-dihydrodehydrodiconiferyl alcohol 4-O-β-D- glucopyranoside were isolated and identified from this genus for the first time. Of these compounds, 5-hydroxy-4'-methoxyflavone-7-O-rutinoside and (7,8,8') -3,3'-dimethoxy- 4,4',9-trihydroxy- 7,9'-epoxy-8,8'-lignan 9-O-rutinoside were potently active against α-glucosidase, while the two dimeric coumarins, 5, 5'-bi (6, 7-dihydroxycoumarin) and 6,6',7,7'-tetrahydroxy-5,8'-bicoumarin potently inhibited HCV protease.
从（同义于牧野）的全株植物中分离出两种木脂素（包括一种新木脂素）、五种黄酮类化合物和五种香豆素。通过对其核磁共振（NMR）、质谱（MS）和圆二色光谱（CD）数据的分析，将新化合物的结构确定为(7,8,8')-3,3'-二甲氧基-4,4',9-三羟基-7,9'-环氧-8,8'-木脂素9-O-芸香糖苷。通过将已知化合物的NMR和MS数据与已报道的数据进行比较来对其进行表征。在这些已知化合物中，5-羟基-4'-甲氧基黄酮-7-O-芸香糖苷、6,7-二-O-β-D-吡喃葡萄糖基七叶亭和7,8-二氢脱氢二松柏醇4-O-β-D-吡喃葡萄糖苷首次从该属中分离并鉴定出来。在这些化合物中，5-羟基-4'-甲氧基黄酮-7-O-芸香糖苷和(7,8,8')-3,3'-二甲氧基-4,4',9-三羟基-7,9'-环氧-8,8'-木脂素9-O-芸香糖苷对α-葡萄糖苷酶具有强效活性，而两种二聚香豆素，5,5'-联（6,7-二羟基香豆素）和6,6',7,7'-四羟基-5,8'-双香豆素对丙型肝炎病毒（HCV）蛋白酶具有强效抑制作用。
