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1
In vitro effect of cyclosporin A on immunoglobulin production and concanavalin A induced suppression in primary biliary cirrhosis.环孢素A对原发性胆汁性肝硬化中免疫球蛋白产生及伴刀豆球蛋白A诱导抑制的体外作用
Gut. 1986 Mar;27(3):317-23. doi: 10.1136/gut.27.3.317.
2
The effect of prednisolone in vitro on immunoglobulin production in primary biliary cirrhosis.泼尼松龙体外对原发性胆汁性肝硬化中免疫球蛋白产生的影响。
Clin Exp Immunol. 1986 Mar;63(3):663-70.
3
Thymosin effects on immunoglobulin synthesis and suppressor T cell activity in normal subjects and patients with primary biliary cirrhosis.
Int J Immunopharmacol. 1986;8(1):119-24. doi: 10.1016/0192-0561(86)90080-9.
4
In vitro studies on the mechanism of increased serum IgM levels in primary biliary cirrhosis.原发性胆汁性肝硬化血清IgM水平升高机制的体外研究
Clin Exp Immunol. 1985 Aug;61(2):297-304.
5
Genetic abnormalities of immunoregulation in primary biliary cirrhosis.原发性胆汁性肝硬化免疫调节的基因异常
Am J Med. 1983 Jul;75(1):75-80. doi: 10.1016/0002-9343(83)91170-1.
6
In vitro immune response of human peripheral lymphocytes. II. Properties and functions of concanavalin A-induced suppressor T cells.人外周淋巴细胞的体外免疫反应。II. 伴刀豆球蛋白A诱导的抑制性T细胞的特性与功能。
Microbiol Immunol. 1979;23(3):185-96. doi: 10.1111/j.1348-0421.1979.tb00455.x.
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Immunoregulation of immunoglobulin production in normal infants and children.正常婴幼儿免疫球蛋白产生的免疫调节
Clin Exp Immunol. 1985 Mar;59(3):679-86.
8
Allogeneic suppression of polyclonal immunoglobulin production in normals and patients with systemic lupus erythematosus.正常人和系统性红斑狼疮患者多克隆免疫球蛋白产生的同种异体抑制。
Clin Exp Immunol. 1980 Oct;42(1):27-32.
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Suppression of immunoglobulin synthesis by activated B cells in chronic active liver diseases and primary biliary cirrhosis.
Gastroenterol Jpn. 1986 Feb;21(1):23-9. doi: 10.1007/BF02775936.
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Effects of cyclosporin A on suppressor and inducer T lymphocytes in primary biliary cirrhosis.环孢素A对原发性胆汁性肝硬化中抑制性和诱导性T淋巴细胞的影响。
Lancet. 1980 Dec 6;2(8206):1223-6. doi: 10.1016/s0140-6736(80)92481-2.

引用本文的文献

1
Primary biliary cirrhosis.原发性胆汁性肝硬化
Gut. 1991 Sep;Suppl(Suppl):S73-8. doi: 10.1136/gut.32.suppl.s73.

本文引用的文献

1
Effect of steroid therapy on the clinical and laboratory features of primary biliary cirrhosis.
Gastroenterology. 1955 Feb;28(2):193-207; discussion, 208-15.
2
Liver transplantation, 1980, with particular reference to cyclosporin-A.肝移植，1980年，特别提及环孢菌素A。
Transplant Proc. 1981 Mar;13(1 Pt 1):281-5.
3
Abnormal regulation of immunoglobulin synthesis in vitro in primary biliary cirrhosis.原发性胆汁性肝硬化中免疫球蛋白合成的体外异常调节
Gastroenterology. 1980 Aug;79(2):242-54.
4
Cyclosporin A and dexamethasone suppress T cell responses by selectively acting at distinct sites of the triggering process.环孢素A和地塞米松通过选择性作用于触发过程的不同位点来抑制T细胞反应。
J Immunol. 1980 Jun;124(6):2828-33.
5
Effects of cyclosporin A on the metabolism of unstimulated and mitogen-activated lymphocytes.环孢素A对未刺激及丝裂原激活淋巴细胞代谢的影响。
Immunology. 1983 May;49(1):153-60.
6
Cyclosporin A blocks receptors for HLA-DR antigens on T cells.环孢素A可阻断T细胞上HLA - DR抗原的受体。
Nature. 1981 Apr 30;290(5809):792-4. doi: 10.1038/290792a0.
7
Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2.环孢素A通过损害白细胞介素1和白细胞介素2的释放来介导对原发性细胞毒性T细胞反应的免疫抑制。
Eur J Immunol. 1981 Aug;11(8):657-61. doi: 10.1002/eji.1830110812.
8
Suppressive effects of cyclosporin A on the induction of alloreactivity in vitro and in vivo.环孢素A对体内外同种异体反应性诱导的抑制作用。
J Immunol. 1981 Jul;127(1):89-93.
9
Effect of cyclosporin A on human lymphocyte responses in vitro. I. CsA allows for the expression of alloantigen-activated suppressor cells while preferentially inhibiting the induction of cytolytic effector lymphocytes in MLR.环孢素A对人淋巴细胞体外反应的影响。I. 环孢素A允许同种异体抗原激活的抑制细胞表达，同时在混合淋巴细胞反应中优先抑制细胞溶解效应淋巴细胞的诱导。
J Immunol. 1980 Jun;124(6):2601-8.
10
Cyclosporin A does not prevent expression of Tac antigen, a probable TCGF receptor molecule, on mitogen-stimulated human T cells.环孢菌素A不能阻止Tac抗原（一种可能的TCGF受体分子）在有丝分裂原刺激的人T细胞上表达。
J Immunol. 1983 Jun;130(6):2737-42.

环孢素A对原发性胆汁性肝硬化中免疫球蛋白产生及伴刀豆球蛋白A诱导抑制的体外作用

In vitro effect of cyclosporin A on immunoglobulin production and concanavalin A induced suppression in primary biliary cirrhosis.

作者信息

Al-Aghbar M N, Alexander G J, Nouri-Aria K T, Neuberger J, Eddleston A L, Williams R

出版信息

Gut. 1986 Mar;27(3):317-23. doi: 10.1136/gut.27.3.317.

DOI:10.1136/gut.27.3.317
PMID:2939007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1433424/
Abstract

The in vitro effect of Cyclosporin A on the regulation of immunoglobulin production was investigated in 16 patients with primary biliary cirrhosis. A significant improvement in concanavalin A induced suppression of IgG and IgM producing cells was observed after prior incubation of mononuclear cells with 300 ng/ml Cyclosporin A for 30 minutes. No effect was seen on spontaneous or pokeweed mitogen induced immunoglobulin production, nor on con A induced suppression if Cyclosporin A was added after 24 hours. Incubation of mononuclear cells with a variable dose of Cyclosporin A showed an effect only at 250-500 ng/ml. Higher and lower doses had no effect. This dose dependent effect of Cyclosporin A is likely to be related to a differential inhibitory effect on T helper and T suppressor cells and may underlie the clinical benefit being observed in current clinical trials.

摘要

在16例原发性胆汁性肝硬化患者中研究了环孢素A对免疫球蛋白产生调节的体外作用。在用300 ng/ml环孢素A将单核细胞预先孵育30分钟后，观察到伴刀豆球蛋白A诱导的IgG和IgM产生细胞的抑制有显著改善。如果在24小时后添加环孢素A，则对自发或商陆有丝分裂原诱导的免疫球蛋白产生没有影响，对伴刀豆球蛋白A诱导的抑制也没有影响。用不同剂量的环孢素A孵育单核细胞仅在250 - 500 ng/ml时显示出作用。更高和更低的剂量没有作用。环孢素A的这种剂量依赖性作用可能与对辅助性T细胞和抑制性T细胞的不同抑制作用有关，并且可能是当前临床试验中观察到的临床益处的基础。