Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park, London SE5 8AF, UK.
Department of Psychological and Behavioural Science, London School of Economics and Political Science, Queens House, 55-56 Lincoln's Inn Fields, London WC2A 3LJ, UK.
Nat Rev Genet. 2018 Mar;19(3):148-159. doi: 10.1038/nrg.2017.104. Epub 2018 Jan 8.
Intelligence - the ability to learn, reason and solve problems - is at the forefront of behavioural genetic research. Intelligence is highly heritable and predicts important educational, occupational and health outcomes better than any other trait. Recent genome-wide association studies have successfully identified inherited genome sequence differences that account for 20% of the 50% heritability of intelligence. These findings open new avenues for research into the causes and consequences of intelligence using genome-wide polygenic scores that aggregate the effects of thousands of genetic variants.
智力——学习、推理和解决问题的能力——是行为遗传学研究的前沿。智力具有高度遗传性，可以比任何其他特征更好地预测重要的教育、职业和健康结果。最近的全基因组关联研究成功地确定了遗传基因组序列差异，这些差异解释了智力 50%可遗传性的 20%。这些发现为使用全基因组多基因评分（聚合数千个遗传变异的影响）研究智力的原因和后果开辟了新的途径。
