智力的新遗传学。
The new genetics of intelligence.
机构信息
Institute of Psychiatry, Psychology and Neuroscience, King's College London, 16 De Crespigny Park, London SE5 8AF, UK.
Department of Psychological and Behavioural Science, London School of Economics and Political Science, Queens House, 55-56 Lincoln's Inn Fields, London WC2A 3LJ, UK.
出版信息
Nat Rev Genet. 2018 Mar;19(3):148-159. doi: 10.1038/nrg.2017.104. Epub 2018 Jan 8.
Abstract
Intelligence - the ability to learn, reason and solve problems - is at the forefront of behavioural genetic research. Intelligence is highly heritable and predicts important educational, occupational and health outcomes better than any other trait. Recent genome-wide association studies have successfully identified inherited genome sequence differences that account for 20% of the 50% heritability of intelligence. These findings open new avenues for research into the causes and consequences of intelligence using genome-wide polygenic scores that aggregate the effects of thousands of genetic variants.
摘要
智力——学习、推理和解决问题的能力——是行为遗传学研究的前沿。智力具有高度遗传性，可以比任何其他特征更好地预测重要的教育、职业和健康结果。最近的全基因组关联研究成功地确定了遗传基因组序列差异，这些差异解释了智力 50%可遗传性的 20%。这些发现为使用全基因组多基因评分（聚合数千个遗传变异的影响）研究智力的原因和后果开辟了新的途径。
相似文献
1
The new genetics of intelligence.智力的新遗传学。
Nat Rev Genet. 2018 Mar;19(3):148-159. doi: 10.1038/nrg.2017.104. Epub 2018 Jan 8.
2
Genome-wide association studies establish that human intelligence is highly heritable and polygenic.全基因组关联研究表明，人类智力具有高度遗传性和多基因性。
Mol Psychiatry. 2011 Oct;16(10):996-1005. doi: 10.1038/mp.2011.85. Epub 2011 Aug 9.
3
Childhood intelligence is heritable, highly polygenic and associated with FNBP1L.儿童智力具有遗传性，是高度多基因的，并与 FNBP1L 相关。
Mol Psychiatry. 2014 Feb;19(2):253-8. doi: 10.1038/mp.2012.184. Epub 2013 Jan 29.
4
A genome-wide association study for extremely high intelligence.全基因组关联研究极高智力
Mol Psychiatry. 2018 May;23(5):1226-1232. doi: 10.1038/mp.2017.121. Epub 2017 Jul 4.
5
The Genetics of Intelligence.智力的遗传学
Dtsch Arztebl Int. 2025 Jan 24;122(2):38-42. doi: 10.3238/arztebl.m2024.0236.
6
A genome-wide analysis of putative functional and exonic variation associated with extremely high intelligence.一项与极高智商相关的假定功能性和外显子变异的全基因组分析。
Mol Psychiatry. 2016 Aug;21(8):1145-51. doi: 10.1038/mp.2015.108. Epub 2015 Aug 4.
7
The Genetics of Success: How Single-Nucleotide Polymorphisms Associated With Educational Attainment Relate to Life-Course Development.成功的遗传学：与受教育程度相关的单核苷酸多态性如何与生命历程发展相关联。
Psychol Sci. 2016 Jul;27(7):957-72. doi: 10.1177/0956797616643070. Epub 2016 Jun 1.
8
A statistical approach to fine-mapping for the identification of potential causal variants related to human intelligence.一种用于精细映射的统计方法，用于鉴定与人类智力相关的潜在因果变异。
J Hum Genet. 2019 Aug;64(8):781-787. doi: 10.1038/s10038-019-0623-3. Epub 2019 Jun 5.
9
Genetics and intelligence differences: five special findings.遗传学与智力差异：五项特殊发现
Mol Psychiatry. 2015 Feb;20(1):98-108. doi: 10.1038/mp.2014.105. Epub 2014 Sep 16.
10
Genetics and general cognitive ability.遗传学与一般认知能力。
Nature. 1999 Dec 2;402(6761 Suppl):C25-9. doi: 10.1038/35011520.
引用本文的文献
1
Do adversities in the intrauterine and neonatal periods interfere with intelligence?子宫内和新生儿期的逆境会影响智力吗？
Rev Saude Publica. 2025 Jun 16;59:e15. doi: 10.11606/s1518-8787.2025059006206. eCollection 2025.
2
Environmental and Genetic Influences on Developmental Outcomes Across the Domains of Language, Cognition, Motor Function, and Social Behavior.环境和遗传对语言、认知、运动功能及社会行为等领域发育结果的影响
Eur J Neurosci. 2025 Jun;61(12):e70163. doi: 10.1111/ejn.70163.
3
Stability of general cognitive ability from infancy to adulthood: A combined twin and genomic investigation.从婴儿期到成年期一般认知能力的稳定性：一项双胞胎与基因组联合研究。
Proc Natl Acad Sci U S A. 2025 May 27;122(21):e2426531122. doi: 10.1073/pnas.2426531122. Epub 2025 May 19.
4
Genomic and Developmental Models to Predict Cognitive and Adaptive Outcomes in Autistic Children.用于预测自闭症儿童认知和适应性结果的基因组与发育模型
JAMA Pediatr. 2025 Apr 21. doi: 10.1001/jamapediatrics.2025.0205.
5
Precision medicine in neuropsychiatric disorders: Still a long way to go.神经精神疾病中的精准医学：仍有很长的路要走。
Dev Med Child Neurol. 2025 Oct;67(10):1248-1249. doi: 10.1111/dmcn.16296. Epub 2025 Mar 23.
6
Genetic contributions to the stability and satisfaction in Sexual Relationships.基因对性关系稳定性和满意度的影响。
Glob Med Genet. 2025 Feb 20;12(2):100043. doi: 10.1016/j.gmg.2025.100043. eCollection 2025 Jun.
7
The Role of Parental Education, Intelligence, and Personality on the Cognitive Abilities of Gifted Children.父母教育、智力和个性对天才儿童认知能力的作用。
J Intell. 2025 Jan 21;13(2):12. doi: 10.3390/jintelligence13020012.
8
Identification of novel proteins associated with intelligence by integrating genome-wide association data and human brain proteomics.通过整合全基因组关联数据和人类大脑蛋白质组学来鉴定与智力相关的新蛋白质。
PLoS One. 2025 Feb 21;20(2):e0319278. doi: 10.1371/journal.pone.0319278. eCollection 2025.
9
Using twin-pairs to assess potential bias in polygenic prediction of externalising behaviours across development.利用双胞胎对评估跨发育过程中外显行为多基因预测中的潜在偏差。
Mol Psychiatry. 2025 Feb 19. doi: 10.1038/s41380-025-02920-6.
10
The Genetic Specificity of Cognitive Tests After Controlling for General Cognitive Ability.控制一般认知能力后认知测试的基因特异性
Behav Genet. 2025 Mar;55(2):103-113. doi: 10.1007/s10519-025-10213-5. Epub 2025 Feb 18.
本文引用的文献
1
Differences in exam performance between pupils attending selective and non-selective schools mirror the genetic differences between them.就读于择优录取学校和非择优录取学校的学生在考试成绩上的差异反映了他们之间的基因差异。
NPJ Sci Learn. 2018 Mar 23;3:3. doi: 10.1038/s41539-018-0019-8. eCollection 2018.
2
Genetics and educational attainment.遗传学与教育成就。
NPJ Sci Learn. 2017 Feb 1;2:4. doi: 10.1038/s41539-017-0005-6. eCollection 2017.
3
Genetic influence on social outcomes during and after the Soviet era in Estonia.爱沙尼亚在苏联时代及之后社会成果中的遗传影响。
Nat Hum Behav. 2018 Apr;2(4):269-275. doi: 10.1038/s41562-018-0332-5. Epub 2018 Apr 9.
4
A genome-wide association study for extremely high intelligence.全基因组关联研究极高智力
Mol Psychiatry. 2018 May;23(5):1226-1232. doi: 10.1038/mp.2017.121. Epub 2017 Jul 4.
5
A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence.一项与遗传相关性状的联合分析确定了 187 个基因座，以及神经发生和髓鞘形成在智力中的作用。
Mol Psychiatry. 2019 Feb;24(2):169-181. doi: 10.1038/s41380-017-0001-5. Epub 2018 Jan 11.
6
Widespread covariation of early environmental exposures and trait-associated polygenic variation.广泛的早期环境暴露与特质相关的多基因变异的共变。
Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):11727-11732. doi: 10.1073/pnas.1707178114. Epub 2017 Oct 16.
7
Concepts, estimation and interpretation of SNP-based heritability.基于 SNP 的遗传力的概念、估计和解释。
Nat Genet. 2017 Aug 30;49(9):1304-1310. doi: 10.1038/ng.3941.
8
Multi-polygenic score approach to trait prediction.多基因评分法进行特征预测。
Mol Psychiatry. 2018 May;23(5):1368-1374. doi: 10.1038/mp.2017.163. Epub 2017 Aug 8.
9
Genetic Influence on Intergenerational Educational Attainment.遗传对代际教育成就的影响。
Psychol Sci. 2017 Sep;28(9):1302-1310. doi: 10.1177/0956797617707270. Epub 2017 Jul 17.
10
Genome-Wide Polygenic Scores Predict Reading Performance Throughout the School Years.全基因组多基因评分可预测整个学年的阅读表现。
Sci Stud Read. 2017 Jul 4;21(4):334-349. doi: 10.1080/10888438.2017.1299152. Epub 2017 Mar 28.
Zotero 插件