Zhou Yunyun, Zou Qi, Qiu Jing, Wang Linjun, Zhu Liangliang
State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University , Shanghai 200433, China.
Shanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power, Shanghai University of Electric Power , Shanghai 200090, China.
J Phys Chem Lett. 2018 Feb 1;9(3):550-556. doi: 10.1021/acs.jpclett.7b03233. Epub 2018 Jan 19.
A controllable sensing ability strongly connects to complex and precise events in diagnosis and treatment. However, imposing visible light into the molecular-scale mediation of sensing processes is restricted by the lack of structural relevance. To address this critical challenge, we present the rational design, synthesis, and in vitro studies of a novel cyanostyryl-modified azulene system for green-light-mediated fast switchable acidic sensing. The advantageous features of the design include a highly efficient green-light-driven Z/E-isomerization (a quantum yield up to 61.3%) for fast erasing chromatic and luminescent expressions and a superior compatibility with control of ratiometric protonation. Significantly, these merits of the design enable the development of a microfluidic system to perform a green-light-mediated reusable sensing function toward a gastric acid analyte in a miniaturized platform. The results may provide new insights for building future integrated green materials.
可控传感能力与诊断和治疗中的复杂精确事件紧密相连。然而，由于缺乏结构相关性，将可见光引入传感过程的分子尺度介导受到限制。为应对这一关键挑战，我们展示了一种新型氰基苯乙烯基修饰薁系统的合理设计、合成及体外研究，用于绿光介导的快速可切换酸性传感。该设计的优势特性包括高效的绿光驱动Z/E异构化（量子产率高达61.3%）以快速消除颜色和发光表现，以及与比例质子化控制的卓越兼容性。值得注意的是，这些设计优点使得能够开发一种微流体系统，在小型化平台上对胃酸分析物执行绿光介导的可重复使用传感功能。这些结果可能为构建未来的集成绿色材料提供新的见解。
