College of Horticulture and Forestry Science, Hubei Engineering Technology Research Center for Forestry Information, Huazhong Agricultural University, Wuhan 430070, China.
Key Laboratory of Horticultural Plant Biology (Ministry of Education), College of Horticulture and Forestry Science, Huazhong Agricultural University, Wuhan 430070, China.
Int J Mol Sci. 2018 Jan 16;19(1):259. doi: 10.3390/ijms19010259.
Auxin plays a crucial role in the diverse cellular and developmental responses of plants across their lifespan. Plants can quickly sense and respond to changes in auxin levels, and these responses involve several major classes of auxin-responsive genes, including the () family, the () family, (), and the () family. Aux/IAA proteins are short-lived nuclear proteins comprising several highly conserved domains that are encoded by the auxin early response gene family. These proteins have specific domains that interact with ARFs and inhibit the transcription of genes activated by ARFs. Molecular studies have revealed that Aux/IAA family members can form diverse dimers with to regulate genes in various ways. Functional analyses of Aux/IAA family members have indicated that they have various roles in plant development, such as root development, shoot growth, and fruit ripening. In this review, recently discovered details regarding the molecular characteristics, regulation, and protein-protein interactions of the Aux/IAA proteins are discussed. These details provide new insights into the molecular basis of the Aux/IAA protein functions in plant developmental processes.
生长素在植物整个生命周期中的各种细胞和发育反应中起着至关重要的作用。植物可以快速感知和响应生长素水平的变化，这些反应涉及几大类生长素响应基因，包括 () 家族、() 家族、() 和 () 家族。Aux/IAA 蛋白是由生长素早期反应基因家族编码的短寿命核蛋白，包含几个高度保守的结构域。这些蛋白质具有与 ARFs 相互作用的特定结构域，并抑制 ARFs 激活的基因的转录。分子研究表明，Aux/IAA 家族成员可以与 () 形成多种二聚体，以各种方式调节基因。对 Aux/IAA 家族成员的功能分析表明，它们在植物发育中具有多种作用，例如根发育、茎生长和果实成熟。在这篇综述中，讨论了最近发现的关于 Aux/IAA 蛋白的分子特征、调节和蛋白-蛋白相互作用的细节。这些细节为 Aux/IAA 蛋白在植物发育过程中的功能的分子基础提供了新的见解。
