Department of Biomedical Engineering, the Department of Chemistry, and the Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California, USA.
Department of Chemical and Biological Engineering and the Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, USA.
Nat Chem Biol. 2018 Jan 16;14(2):103-106. doi: 10.1038/nchembio.2554.
The central dogma processes of DNA replication, transcription, and translation are responsible for the maintenance and expression of every gene in an organism. An orthogonal central dogma may insulate genetic programs from host regulation and allow expansion in the roles of these processes within the cell.
DNA 复制、转录和翻译的中心法则过程负责维持和表达生物体中每个基因。正交中心法则可以使遗传程序与宿主调控隔离，并允许这些过程在细胞内的作用扩展。
