Psychedelic Research Group, Department of Medicine, Imperial College London, UK.
J Psychopharmacol. 2018 Jul;32(7):811-819. doi: 10.1177/0269881117748902. Epub 2018 Jan 17.
Previous research suggests that classical psychedelic compounds can induce lasting changes in personality traits, attitudes and beliefs in both healthy subjects and patient populations.
Here we sought to investigate the effects of psilocybin on nature relatedness and libertarian-authoritarian political perspective in patients with treatment-resistant depression (TRD).
This open-label pilot study with a mixed-model design studied the effects of psilocybin on measures of nature relatedness and libertarian-authoritarian political perspective in patients with moderate to severe TRD ( n=7) versus age-matched non-treated healthy control subjects ( n=7). Psilocybin was administered in two oral dosing sessions (10 mg and 25 mg) 1 week apart. Main outcome measures were collected 1 week and 7-12 months after the second dosing session. Nature relatedness and libertarian-authoritarian political perspective were assessed using the Nature Relatedness Scale (NR-6) and Political Perspective Questionnaire (PPQ-5), respectively.
Nature relatedness significantly increased ( t(6)=-4.242, p=0.003) and authoritarianism significantly decreased ( t(6)=2.120, p=0.039) for the patients 1 week after the dosing sessions. At 7-12 months post-dosing, nature relatedness remained significantly increased ( t(5)=-2.707, p=0.021) and authoritarianism remained decreased at trend level ( t(5)=-1.811, p=0.065). No differences were found on either measure for the non-treated healthy control subjects.
This pilot study suggests that psilocybin with psychological support might produce lasting changes in attitudes and beliefs. Although it would be premature to infer causality from this small study, the possibility of drug-induced changes in belief systems seems sufficiently intriguing and timely to deserve further investigation.
先前的研究表明，经典迷幻化合物可在健康受试者和患者人群中诱导持久的人格特质、态度和信念改变。
本研究旨在探讨迷幻蘑菇对治疗抵抗性抑郁症（TRD）患者的自然关联性和自由意志主义-专制主义政治观点的影响。
本项开放标签、混合模型设计的初步研究，旨在研究迷幻蘑菇对中重度 TRD 患者（ n=7）与年龄匹配的未经治疗的健康对照受试者（ n=7）的自然关联性和自由意志主义-专制主义政治观点测量值的影响。迷幻蘑菇以 1 周的间隔进行 2 次口服给药（10mg 和 25mg）。主要结局指标在第 2 次给药后 1 周和 7-12 个月收集。自然关联性采用自然关联性量表（NR-6）评估，自由意志主义-专制主义政治观点采用政治观点问卷（PPQ-5）评估。
给药后 1 周，患者的自然关联性显著增加（ t(6)=-4.242， p=0.003），专制主义显著降低（ t(6)=2.120， p=0.039）。给药后 7-12 个月，自然关联性仍显著增加（ t(5)=-2.707， p=0.021），专制主义仍呈下降趋势（ t(5)=-1.811， p=0.065）。未经治疗的健康对照受试者在这两个测量指标上均无差异。
本初步研究表明，在心理支持下，迷幻蘑菇可能会导致态度和信念的持久改变。虽然从这项小型研究中推断因果关系还为时过早，但药物诱导的信仰体系改变的可能性似乎足够有趣和及时，值得进一步研究。
