Centre for Neuropsychopharmacology, Division of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK.
South London and Maudsley NHS Foundation Trust, London, UK.
Acta Psychiatr Scand. 2018 Nov;138(5):368-378. doi: 10.1111/acps.12904. Epub 2018 Jun 19.
To explore whether psilocybin with psychological support modulates personality parameters in patients suffering from treatment-resistant depression (TRD).
Twenty patients with moderate or severe, unipolar, TRD received oral psilocybin (10 and 25 mg, one week apart) in a supportive setting. Personality was assessed at baseline and at 3-month follow-up using the Revised NEO Personality Inventory (NEO-PI-R), the subjective psilocybin experience with Altered State of Consciousness (ASC) scale, and depressive symptoms with QIDS-SR16.
Neuroticism scores significantly decreased while Extraversion increased following psilocybin therapy. These changes were in the direction of the normative NEO-PI-R data and were both predicted, in an exploratory analysis, by the degree of insightfulness experienced during the psilocybin session. Openness scores also significantly increased following psilocybin, whereas Conscientiousness showed trend-level increases, and Agreeableness did not change.
Our observation of changes in personality measures after psilocybin therapy was mostly consistent with reports of personality change in relation to conventional antidepressant treatment, although the pronounced increases in Extraversion and Openness might constitute an effect more specific to psychedelic therapy. This needs further exploration in future controlled studies, as do the brain mechanisms of postpsychedelic personality change.
探索在接受难治性抑郁症（TRD）治疗的患者中，给予心理支持的裸盖菇素是否会调节人格参数。
20 名中重度、单相、TRD 患者在支持性环境中接受口服裸盖菇素（10 和 25mg，间隔一周）治疗。采用修订后的 NEO 人格量表（NEO-PI-R）、意识改变的主观裸盖菇素体验量表（ASC 量表）和 QIDS-SR16 在基线和 3 个月随访时评估人格。
裸盖菇素治疗后，神经质评分显著降低，外向性评分增加。这些变化与 NEO-PI-R 数据的正常方向一致，并且在探索性分析中，与裸盖菇素治疗期间体验到的洞察力程度相关。治疗后，开放性评分也显著增加，而尽责性评分呈上升趋势，宜人性评分没有变化。
我们观察到的人格测量变化与常规抗抑郁治疗相关的人格变化报告大多一致，尽管外向性和开放性的明显增加可能构成更特定于迷幻治疗的效果。这需要在未来的对照研究中进一步探索，以及迷幻后人格变化的大脑机制。
