植物再生过程中的动态表观遗传变化。

Dynamic Epigenetic Changes during Plant Regeneration.

机构信息

Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, Republic of Korea.

出版信息

Trends Plant Sci. 2018 Mar;23(3):235-247. doi: 10.1016/j.tplants.2017.11.009. Epub 2018 Jan 12.

DOI:10.1016/j.tplants.2017.11.009

Abstract

Plants have the remarkable ability to drive cellular dedifferentiation and regeneration. Changes in epigenetic landscapes accompany the cell fate transition. Notably, modifications of chromatin structure occur primarily during callus formation via an in vitro tissue culture process and, thus, pluripotent callus cells have unique epigenetic signatures. Here, we highlight the latest progress in epigenetic regulation of callus formation in plants, which addresses fundamental questions related to cell fate changes and pluripotency establishment. Global and local modifications of chromatin structure underlie callus formation, and the combination and sequence of epigenetic modifications further shape intricate cell fate changes. This review illustrates how a series of chromatin marks change dynamically during callus formation and their biological relevance in plant regeneration.

摘要

植物具有驱动细胞去分化和再生的显著能力。表观遗传景观的变化伴随着细胞命运的转变。值得注意的是，染色质结构的修饰主要发生在通过体外组织培养过程形成愈伤组织的过程中，因此，多能愈伤组织细胞具有独特的表观遗传特征。在这里，我们强调了植物愈伤组织形成过程中表观遗传调控的最新进展，该进展解决了与细胞命运变化和多能性建立相关的基本问题。染色质结构的全局和局部修饰是愈伤组织形成的基础，而表观遗传修饰的组合和顺序进一步塑造了复杂的细胞命运变化。本综述说明了在愈伤组织形成过程中一系列染色质标记如何动态变化及其在植物再生中的生物学相关性。