Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Taiwan; Chang Gung University College of Medicine, Kaohsiung, Taiwan; Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Taiwan; Chang Gung University College of Medicine, Kaohsiung, Taiwan.
J Formos Med Assoc. 2018 Nov;117(11):973-978. doi: 10.1016/j.jfma.2017.11.001. Epub 2018 Jan 12.
Acid changes in gastroesophageal reflux with vary component in the food have less been studied, especially carbohydrate. We plan to clarify the effect of different carbohydrate density on low esophageal acid and reflux symptoms of patients with gastroesophgeal reflux disease.
Twelve patients (52 ± 12 years old; five female) with gastroesophageal reflux disease were recruited for the prospective crossover study. Each patient was invited for panendoscope, manometry and 24 h pH monitor. The two formulated liquid meal, test meal A: 500 ml liquid meal (containing 84.8 g carbohydrate) and B: same volume liquid meal (but 178.8 g carbohydrate) were randomized supplied as lunch or dinner. Reflux symptoms were recorded.
There are significant statistic differences in more Johnson-DeMeester score (p = 0.019), total reflux time (%) (p = 0.028), number of reflux periods (p = 0.026) and longest reflux (p = 0.015) after high carbohydrate diet than low carbohydrate. Total reflux time and number of long reflux periods more than 5 min are significant more after high carbohydrate diet.
More acid reflux symptoms are found after high carbohydrate diet. High carbohydrate diet could induce more acid reflux in low esophagus and more reflux symptoms in patients with gastroesophageal reflux disease.
食物中不同成分（尤其是碳水化合物）引起的胃食管反流酸变化研究较少。我们计划阐明不同碳水化合物密度对胃食管反流病患者食管下段酸和反流症状的影响。
12 例胃食管反流病患者（52±12 岁；女性 5 例）参与前瞻性交叉研究。每位患者均接受全内镜、测压和 24 小时 pH 监测。两种配方的液体餐，试验餐 A：500ml 液体餐（含 84.8g 碳水化合物）和 B：相同体积的液体餐（但含 178.8g 碳水化合物），随机作为午餐或晚餐供应。记录反流症状。
高碳水化合物饮食后，约翰逊-德梅斯特评分（p=0.019）、总反流时间（%）（p=0.028）、反流次数（p=0.026）和最长反流时间（p=0.015）均有统计学差异。高碳水化合物饮食后总反流时间和长反流时间>5 分钟的次数明显增多。
高碳水化合物饮食后发现更多的酸反流症状。高碳水化合物饮食可引起胃食管反流病患者食管下段酸反流和更多反流症状。
