Thakkar Jigisha P, Slevin John T, Smith Charles D, Sudhakar Padmaja, St Clair William, Villano John L
Department of Neurology, University of Kentucky, Lexington, Kentucky, USA.
Neurology Service, Veterans Affairs Medical Center, Lexington, Kentucky, USA.
Neuroophthalmology. 2017 May 30;41(5):287-290. doi: 10.1080/01658107.2017.1322989. eCollection 2017 Oct.
Radiation optic neuropathy (RON) is an iatrogenic complication that causes severe, irreversible vision loss within months to years following radiation to lesions close to the visual pathway. The authors describe a case of RON in glioblastoma after radio-sensitisation with temozolomide with sequential involvement of both optic nerves. This case provides a timeline for clinical and imaging findings with RON and specifically resolution of nerve enhancement. The authors also highlight the potential of an increase in incidence of RON in glioblastoma with advances in survival seen with greater use of second-line chemotherapy and even re-radiation.
放射性视神经病变（RON）是一种医源性并发症，在对视神经通路附近病变进行放疗后的数月至数年内，可导致严重的、不可逆的视力丧失。作者描述了1例胶质母细胞瘤患者在使用替莫唑胺进行放射增敏后发生RON的病例，双侧视神经相继受累。该病例提供了RON的临床和影像学表现的时间线，特别是神经强化的消退情况。作者还强调，随着二线化疗甚至再放疗的更多使用，胶质母细胞瘤患者的生存率提高，RON的发病率可能会增加。
