Li Xiaohong, Lee Katie J, Duffy David L, Xu Dandan, Basude Madhur Eshwar Rao, Hu Ying, Zhang Hang, Jagirdar Kasturee, Soyer H Peter, Dong Huiting, Sturm Richard A
Department of Dermatology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.
Key-Disciplines Laboratory, Clinical-Medicine Henan, Zhengzhou, Henan, China.
PeerJ. 2017 Dec 20;5:e4168. doi: 10.7717/peerj.4168. eCollection 2017.
Early detection and treatment are the most important elements in reducing the incidence of melanoma deaths. Acquired melanocytic naevi (AMN) are well-known precursors of melanoma but most of our knowledge on the clinico-dermoscopic phenotypes of AMN is based on studies in European-background populations, particularly American and Australian populations. There has been little research in Chinese Han populations on clinico-dermoscopic variability of naevi or how naevi are affected by melanoma-linked variants of the melanocortin 1 receptor () gene.
Clinical and dermoscopic features of 448 AMN in 115 patients from the Han ethnic group in mainland China were described. Germline polymorphisms in were determined for 98 of these patients.
AMN were predominantly found on the head and neck. Dermoscopic patterns observed were nonspecific, reticular, globular, and parallel furrow, with most AMN having a nonspecific pattern. There were no associations between polymorphisms and clinical or dermoscopic features of AMN.
Our results provide evidence that AMN in the Han population in China have similar dermoscopic patterns to those in European populations, but are present in much lower numbers. As there were no associations between clinical or dermoscopic features of AMN and polymorphisms, further studies should focus on candidate gene associations with AMN features and the risk of melanoma, with larger sample sizes and comparisons to AMN in other populations.
早期发现和治疗是降低黑色素瘤死亡率的最重要因素。获得性黑素细胞痣（AMN）是黑色素瘤众所周知的前体，但我们对AMN临床皮肤镜表型的了解大多基于对欧洲背景人群的研究，特别是美国和澳大利亚人群。关于中国汉族人群中痣的临床皮肤镜变异性或痣如何受黑素皮质素1受体（）基因的黑色素瘤相关变体影响的研究很少。
描述了中国大陆汉族115例患者中448个AMN的临床和皮肤镜特征。对其中98例患者的种系多态性进行了测定。
AMN主要见于头颈部。观察到的皮肤镜模式为非特异性、网状、球状和平行沟状，大多数AMN具有非特异性模式。AMN的多态性与临床或皮肤镜特征之间无关联。
我们的结果提供了证据，表明中国汉族人群中的AMN与欧洲人群中的AMN具有相似的皮肤镜模式，但数量要少得多。由于AMN的临床或皮肤镜特征与多态性之间无关联，进一步的研究应集中于与AMN特征和黑色素瘤风险相关的候选基因关联，样本量要更大，并与其他人群中的AMN进行比较。
