Hong Chenglv, Zhou Xinlang, Huang Weijian, Shan Peiren, Dong Fengquan
Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Department of Cardiology, Wenzhou City Hospital of Traditional Chinese Medicine and Western Medicine Combined, Wenzhou, Zhejiang, China.
Braz J Med Biol Res. 2018 Jan 11;51(3):e7050. doi: 10.1590/1414-431X20177050.
A new microporous lanthanide metal-organic framework, {[Yb(BTB)(H2O) (DEF)2}n (1, DEF=N,N-Diethylformamide), with 1D nano-sized channels has been constructed by bridging helical chain secondary building units with 1,3,5-benzenetrisbenzoic acid (H3BTB) ligand. Structural characterization suggests that this complex crystallizes in the hexagonal space group P6122 and possesses 1D triangular channels with coordinated water molecules pointing to the channel center. In addition, anti-myocarditis properties of compound 1 were evaluated in vivo. The results showed that compound 1 can improve hemodynamic parameters of, and it may be a good therapeutic option for heart failure in the future.
一种新型的微孔镧系金属有机框架{[Yb(BTB)(H₂O)(DEF)₂}ₙ（1，DEF = N，N - 二乙基甲酰胺），具有一维纳米尺寸的通道，是通过用1,3,5 - 苯三苯甲酸（H₃BTB）配体连接螺旋链二级结构单元构建而成。结构表征表明，该配合物结晶于六方空间群P6₁2₂，拥有一维三角形通道，配位水分子指向通道中心。此外，在体内评估了化合物1的抗心肌炎特性。结果表明，化合物1可以改善血流动力学参数，并且它可能是未来心力衰竭的一种良好治疗选择。
