Güden-Silber Tuba, Temme Sebastian, Jacoby Christoph, Flögel Ulrich
Experimental Cardiovascular Imaging, Department of Molecular Cardiology, Heinrich Heine University, Düsseldorf, Germany.
Methods Mol Biol. 2018;1718:235-257. doi: 10.1007/978-1-4939-7531-0_14.
Background-free fluorine (F) MR imaging exhibits an excellent degree of specificity, and facilitates among others the in vivo visualization of inflammatory processes. MergingF MR images with morphologically matchingH MR images enables the exact anatomic localization of the observedF signal. Biochemically inert nanoemulsions of perfluorocarbons, which are known to be taken up by the macrophage/monocyte system, are widely used as contrast agents for preclinical applications. Herein, the most common protocols are described to obtain high-resolution and artifact-freeF MR images even for compounds with complexF MR spectra. In addition, we report on the utilization of perfluorocarbons with individual spectral identities and targeting approaches to specifically visualize thrombi byF MRI.
无背景氟（F）磁共振成像具有极高的特异性，尤其有助于在体内可视化炎症过程。将F磁共振图像与形态匹配的H磁共振图像合并，能够对观察到的F信号进行精确的解剖定位。全氟化碳的生化惰性纳米乳剂已知可被巨噬细胞/单核细胞系统摄取，被广泛用作临床前应用的造影剂。本文描述了即使对于具有复杂F磁共振谱的化合物，获取高分辨率且无伪影的F磁共振图像的最常用方案。此外，我们报告了利用具有个体光谱特征的全氟化碳和靶向方法，通过F磁共振成像特异性地可视化血栓。
