Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Laboratory of Molecular Biology, Kadki 24, 80-822 Gdańsk, Poland.
Department of Medical Biology and Genetics, University of Gdańsk, Wita Stwosza 59, 80-308 Gdańsk, Poland.
Int J Mol Sci. 2018 Jan 15;19(1):247. doi: 10.3390/ijms19010247.
Research in recent years has shown that sphingolipids are essential signalling molecules for the proper biological and structural functioning of cells. Long-term studies on the metabolism of sphingolipids have provided evidence for their role in the pathogenesis of a number of diseases. As many inflammatory diseases, such as lysosomal storage disorders and some dermatologic diseases, including psoriasis, atopic dermatitis and ichthyoses, are associated with the altered composition and metabolism of sphingolipids, more studies precisely determining the responsibilities of these compounds for disease states are required to develop novel pharmacological treatment opportunities. It is worth emphasizing that knowledge from the study of inflammatory metabolic diseases and especially the possibility of their treatment may lead to insight into related metabolic pathways, including those involved in the formation of the epidermal barrier and providing new approaches towards workable therapies.
近年来的研究表明，神经鞘脂类是细胞正常生物和结构功能所必需的信号分子。对神经鞘脂类代谢的长期研究为其在多种疾病发病机制中的作用提供了证据。由于许多炎症性疾病，如溶酶体贮积症和一些皮肤科疾病，包括银屑病、特应性皮炎和鱼鳞癣，与神经鞘脂类的组成和代谢改变有关，因此需要更多的研究来精确确定这些化合物在疾病状态中的责任，以开发新的药理学治疗机会。值得强调的是，来自炎症性代谢性疾病研究的知识，特别是其治疗的可能性，可能会深入了解相关的代谢途径，包括参与表皮屏障形成的途径，并为可行的治疗方法提供新的途径。
