Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
J Clin Microbiol. 2018 Mar 26;56(4). doi: 10.1128/JCM.01507-17. Print 2018 Apr.
Buruli ulcer is caused by This neglected disease occurs in scattered foci around the world, with a higher concentration of cases in West Africa. The mycobacteria produce mycolactones that cause tissue necrosis. The disease presents as a painless skin nodule that ulcerates as necrosis expands. Finding acid-fast bacilli in smears or histopathology, culturing the mycobacteria, and performing PCR in presumptive cases confirm the diagnosis. Medical treatment with oral rifampin and intramuscular streptomycin or oral treatment with rifampin plus clarithromycin for 8 weeks is supported by the World Health Organization. This review summarizes the epidemiology, pathogenesis, clinical presentation, diagnostic tests, and advances in treatment.
布鲁里溃疡由 引起。这种被忽视的疾病发生在世界各地的分散病灶中，西非的病例更为集中。分枝杆菌产生导致组织坏死的(mycolactones)。该疾病表现为无痛性皮肤结节，随着坏死的扩大而溃疡。在疑似病例中，通过涂片或组织病理学找到抗酸杆菌、培养分枝杆菌以及进行 PCR 可确诊。世界卫生组织支持使用口服利福平和肌肉注射链霉素或口服利福平加克拉霉素治疗 8 周。本综述总结了该病的流行病学、发病机制、临床表现、诊断检测和治疗进展。
