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基于三个实例对儿童接触含乙醇物质及乙醇中毒情况的概述。

An overview of exposure to ethanol-containing substances and ethanol intoxication in children based on three illustrated cases.

作者信息

Hon Kam Lun, Leung Alexander Kc, Cheung Eddie, Lee Bryan, Tsang Michelle Mc, Torres Alcy R

机构信息

Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.

Department of Pediatrics, University of Calgary, Calgary, Alberta, Canada.

出版信息

Drugs Context. 2018 Jan 9;7:212512. doi: 10.7573/dic.212512. eCollection 2018.

Abstract

Alcohol addiction and intoxication are major health problems worldwide. Acute alcohol intoxication is well reported in adults and adolescents but less frequently reported in children of younger ages. We report three anonymized cases of pediatric ethanol exposure and illustrate the different mechanisms of intoxication. In all cases, a focused history is the key to prompt diagnosis and timely management. Physicians should be aware of this potential poison in children presented with acute confusional or encephalopathic state. In contrast, neonates with ethanol intoxication may present with nonspecific gastrointestinal symptomatology. Urgent exclusion of sepsis, electrolyte imbalance, drug intoxication, and surgical abdominal condition is critical. Using these illustrated cases, we performed a narrative literature review on issues of exposure to ethanol-containing substances and ethanol intoxication in children. In conclusion, a high level of suspicion and interrogation on ethanol or substance use are essential particularly in the lactating mother for an accurate and timely diagnosis of ethanol intoxication to be made.

摘要

酒精成瘾和中毒是全球主要的健康问题。急性酒精中毒在成人和青少年中已有充分报道,但在低龄儿童中报道较少。我们报告了3例匿名的儿童乙醇暴露病例,并阐述了不同的中毒机制。在所有病例中,详细的病史是快速诊断和及时处理的关键。对于出现急性意识模糊或脑病状态的儿童,医生应意识到这种潜在的毒物。相比之下,乙醇中毒的新生儿可能表现出非特异性的胃肠道症状。紧急排除败血症、电解质失衡、药物中毒和腹部外科疾病至关重要。利用这些病例,我们对儿童接触含乙醇物质和乙醇中毒问题进行了叙述性文献综述。总之,高度怀疑并询问乙醇或物质使用情况至关重要,特别是对于哺乳期母亲,以便准确及时地诊断乙醇中毒。

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