Radwan Mahmoud, Elsous Aymen, Al-Sharif Hasnaa, Abu Mustafa Ayman
Department of Health Management and Economics, School of Public Health, Tehran University of Medical Sciences - International campus, Tehran, Iran Islamic Republic; and International Cooperation Department, Ministry of Health, Gaza Strip, Palestinian Territory, Occupied.
Assistant Professor, Faculty of Health Sciences, Israa University, Gaza Strip, Palestinian Territory, Occupied; and Quality Improvement and Infection Control, Shifa Medical Complex, Gaza Strip, Palestinian Territory, Occupied.
Ther Adv Endocrinol Metab. 2018 Jan;9(1):3-14. doi: 10.1177/2042018817742070. Epub 2017 Dec 5.
In this study, we aimed to assess the level of good glycemic control, to determine association between adherence to antidiabetic medications and glycosylated hemoglobin (HbA1c) and to examine factors influencing good glycemic control.
A cross-sectional design was employed among 369 patients with type 2 diabetes mellitus (T2DM) from four Ministry of Health health centers in 2016. A sample of 3 ml blood was taken to measure the HbA1c, and patients were asked to fill out a pretested questionnaire. Univariate and multivariate logistic regressions, to identify independent factors associated with good glycemic control, were conducted using SPSS software version 22 (IBM Corp, Armonk, NY, USA).
Mean [±standard deviation (SD)] of HbA1c was 8.97 (2.02) and one fifth of patients had good glycemic control (HbA1c ⩽ 7%). Factors associated with good glycemic control were: older age [odds ratio (OR) = 0.96, 95% confidence interval (CI): 0.933-0.988), high medication adherence (OR: 2.757, 95% CI: 1.308-4.693), and better health literacy (OR= 2.124, 95% CI: 1.917-4.921). Duration of diabetes mellitus (DM > 7 years) was inversely related to good glycemic control (OR = 2.255, 95% CI: 1.189-4.276).
Our study showed that glycemic control was suboptimal, and factors associated with that were: older age, high medication adherence, and better health literacy. Knowledge of these factors could be an entry toward helping patients and targeting interventions to improve glycemic control and prevent diabetes-related complications.
在本研究中,我们旨在评估血糖良好控制水平,确定抗糖尿病药物依从性与糖化血红蛋白(HbA1c)之间的关联,并研究影响血糖良好控制的因素。
2016年,在卫生部的四个健康中心对369例2型糖尿病(T2DM)患者采用横断面设计。采集3ml血液样本以测量HbA1c,并要求患者填写一份经过预测试的问卷。使用SPSS 22软件(美国纽约州阿蒙克市IBM公司)进行单因素和多因素逻辑回归分析,以确定与血糖良好控制相关的独立因素。
HbA1c的平均值[±标准差(SD)]为8.97(2.02),五分之一的患者血糖控制良好(HbA1c⩽7%)。与血糖良好控制相关的因素有:年龄较大[比值比(OR)=0.96,95%置信区间(CI):0.933 - 0.988]、药物依从性高(OR:2.757,95%CI:1.308 - 4.693)以及健康素养较高(OR = 2.124,95%CI:1.917 - 4.921)。糖尿病病程(DM>7年)与血糖良好控制呈负相关(OR = 2.255,95%CI:1.189 - 4.276)。
我们的研究表明血糖控制不理想,与之相关的因素有:年龄较大、药物依从性高以及健康素养较高。了解这些因素可能是帮助患者并针对性进行干预以改善血糖控制和预防糖尿病相关并发症的切入点。